一种无致热原性的新型合成胞壁酰肽佐剂的生物活性。
Biological activity of a new synthetic muramyl peptide adjuvant devoid of pyrogenicity.
作者信息
Chedid L A, Parant M A, Audibert F M, Riveau G J, Parant F J, Lederer E, Choay J P, Lefrancier P L
出版信息
Infect Immun. 1982 Feb;35(2):417-24. doi: 10.1128/iai.35.2.417-424.1982.
Abstract
Immunostimulant activities of muramyl dipeptide (enhancement of specific immune responses and of nonspecific resistance to infection) were retained by its N-acetylmuramyl-L-alanyl-D-glutaminyl-n-butyl ester derivative, although very large amounts administered intravenously, or even by the very sensitive intracerebroventricular route, did not elicit fever in the rabbit. This analog also appeared to be devoid of other secondary effects which have been observed after administration of muramyl dipeptide.
摘要
胞壁酰二肽的免疫刺激活性（增强特异性免疫反应和对感染的非特异性抵抗力）在其N - 乙酰胞壁酰 - L - 丙氨酰 - D - 谷氨酰胺 - 正丁酯衍生物中得以保留，尽管静脉内给予极大量，甚至通过非常敏感的脑室内途径给药，也不会引起兔子发热。该类似物似乎也没有在给予胞壁酰二肽后观察到的其他副作用。
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