内源性逆转录病毒糖蛋白70在正常小鼠抗原激活的细胞毒性和抑制性T淋巴细胞中的表达
Expression of endogenous retroviral glycoprotein 70 by antigen-activated cytotoxic and suppressor T lymphocytes of nice.
作者信息
Klenner D, Horak I, Schimpl A, Wecker E
出版信息
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1250-3. doi: 10.1073/pnas.79.4.1250.
Concanavalin A-stimulated murine spleen cells and antigen-stimulated B lymphocytes of normal mice express an antigen that reacts with goat antiserum against glycoprotein (gp) 70. Structural analysis of this antigen characterizes it as endogenous viral gp70 that is most likely of xenotropic origin. Activated nonspecific T suppressor cells and cytotoxic T lymphocytes express endogenous viral gp70, whereas nonactivated mouse T or B lymphocytes do not. The presence of endogenous retroviral gp70 is thus a novel marker for activated mouse lymphocytes in general.
伴刀豆球蛋白A刺激的小鼠脾细胞和正常小鼠的抗原刺激B淋巴细胞表达一种可与抗糖蛋白（gp）70的山羊抗血清发生反应的抗原。对该抗原的结构分析表明，它是内源性病毒gp70，很可能源自嗜异性病毒。活化的非特异性T抑制细胞和细胞毒性T淋巴细胞表达内源性病毒gp70，而未活化的小鼠T或B淋巴细胞则不表达。因此，内源性逆转录病毒gp70的存在总体上是活化小鼠淋巴细胞的一种新标志物。
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