Anggård A, Lundberg J M, Lundblad L
Eur J Respir Dis Suppl. 1983;128 (Pt 1):143-9.
Studies of the nasal autonomic innervation in cat, rat and man have demonstrated the presence of Substance P (SP), Vasoactive Intestinal Polypeptide (VIP) and Pancreatic Polypeptide (PP) immunoreactivity in the classical pathways. SP was principally confined to the sensory neurones with nerve endings in the spinal trigeminal nucleus, around sphenopalatine ganglion cells and around blood vessels as well as under or within the nasal epithelium. VIP was located to parasympathetic postganglionic cholinergic neurones innervating blood vessels and glands. PP was found in a population of nor-adrenergic ganglion cells in the superior sympathetic ganglia and innervating arteries in the mucosa selectively. The recent findings suggest a hypothesis of a local reflex arch involving antidromic vasodilation by afferent, capsaicin sensitive SP neurones and parasympathetic VIP-cholinergic neurones in the efferent response.
对猫、大鼠和人类鼻自主神经支配的研究表明，在经典通路中存在P物质（SP）、血管活性肠多肽（VIP）和胰多肽（PP）免疫反应性。SP主要局限于感觉神经元，其神经末梢位于脊髓三叉神经核、蝶腭神经节细胞周围、血管周围以及鼻上皮下方或内部。VIP定位于支配血管和腺体的副交感节后胆碱能神经元。PP在交感神经节中的一群去甲肾上腺素能神经节细胞中发现，并选择性地支配黏膜中的动脉。最近的研究结果提出了一个局部反射弧的假说，该反射弧涉及传入的、对辣椒素敏感的SP神经元的逆向血管舒张和传出反应中的副交感VIP胆碱能神经元。
