伴放线放线杆菌提取物对角质形成细胞增殖的抑制作用。
Inhibition of keratinocyte proliferation by extracts of Actinobacillus actinomycetemcomitans.
作者信息
Kamen P R
出版信息
Infect Immun. 1983 Dec;42(3):1191-4. doi: 10.1128/iai.42.3.1191-1194.1983.
Abstract
A heat-labile sonic extract of a nonleukotoxic strain of Actinobacillus actinomycetemcomitans caused a dose-dependent inhibition of proliferation of human keratinocytes. Exposure of cells to heat-labile sonic extract for periods as brief as 10 min produced significant suppression of [3H]thymidine uptake 72 h later. I propose that alteration of epithelial barriers may be one pathogenic mechanism of this organism.
摘要
伴放线放线杆菌非白细胞毒性菌株的热不稳定超声提取物对人角质形成细胞的增殖具有剂量依赖性抑制作用。将细胞暴露于热不稳定超声提取物中短短10分钟，72小时后即可显著抑制[3H]胸腺嘧啶核苷摄取。我认为上皮屏障的改变可能是该生物体的一种致病机制。
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本文引用的文献
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Release of toxic microvesicles by Actinobacillus actinomycetemcomitans.伴放线放线杆菌释放有毒微囊泡。
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