腺病毒12型病毒基因组的左半部分足以诱导干扰素产生。
The left part of the viral genome is sufficient for interferon induction by adenovirus type 12.
作者信息
Tóth M, Béládi I, Weber J
出版信息
Arch Virol. 1984;79(1-2):45-53. doi: 10.1007/BF01314302.
PMID:6199003
Abstract
Adenovirus type 12 is a potent interferon inducer on chick embryo cells. Incomplete particles induce similar levels of interferon as complete virions, even if they contain only the left 20 per cent of the genome. Empty capsids lacking DNA are not able to induce interferon, suggesting that part of the viral genome is required to trigger the cells to produce interferon.
摘要
12型腺病毒是鸡胚细胞上一种有效的干扰素诱导剂。即使不完全颗粒仅包含基因组的左20%，它们诱导的干扰素水平也与完整病毒粒子相似。缺乏DNA的空衣壳不能诱导干扰素，这表明病毒基因组的一部分是触发细胞产生干扰素所必需的。
Zotero 插件