针对人类肿瘤淋巴细胞表面免疫球蛋白产生的抗独特型血清。
Anti-idiotype sera raised against surface immunoglobulin of human neoplastic lymphocytes.
作者信息
Hough D W, Eady R P, Hamblin T J, Stevenson F K, Stevenson G T
出版信息
J Exp Med. 1976 Oct 1;144(4):960-9. doi: 10.1084/jem.144.4.960.
Abstract
The idiotypic determinants of surface immunoglobulins on B-cell lymphomas and lymphocytic leukemias represent tumor-specific antigens, individually unique for each tumor. As such they have both diagnostic and therapeutic potential, particularly for those neoplasms with no serum monoclonal immunoglobulin arising from synthesis of the protein for export. We describe the raising in animals of anti-idiotype sera directed against two examples of a nonexporting neoplasm, human chronic lymphocytic leukemia. The procedure involves exposing the cells to papain so as to remove the Fab fragments (containing the idiotypic determinants) from the surface immunoglobulin, recovering the Fab on cellulose immunosorbent particles, and immunizing animals with the immunosorbent-Fab complex.
摘要
B细胞淋巴瘤和淋巴细胞白血病表面免疫球蛋白的独特型决定簇代表肿瘤特异性抗原，每个肿瘤都具有个体独特性。因此，它们具有诊断和治疗潜力，特别是对于那些没有因蛋白质分泌合成而产生血清单克隆免疫球蛋白的肿瘤。我们描述了针对非分泌型肿瘤（人类慢性淋巴细胞白血病）的两个实例在动物体内制备抗独特型血清的过程。该过程包括将细胞暴露于木瓜蛋白酶，以便从表面免疫球蛋白中去除Fab片段（含有独特型决定簇），在纤维素免疫吸附颗粒上回收Fab，并使用免疫吸附-Fab复合物免疫动物。
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Chemical coupling of proteins to agarose.蛋白质与琼脂糖的化学偶联。
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Idiotypic specificity of surface immunoglobulin and the maturation of leukemic bone-marrow-derived lymphocytes.表面免疫球蛋白的独特型特异性与白血病骨髓来源淋巴细胞的成熟
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Early changes in immunoglobulin M synthesis after mitogenic stimulation of bone marrow derived lymphocytes.骨髓来源淋巴细胞经有丝分裂原刺激后免疫球蛋白M合成的早期变化
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Recovery of immunoglobulin removed from lymphocytic surfaces by proteolysis.通过蛋白水解作用从淋巴细胞表面去除的免疫球蛋白的恢复。
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IgM in bone marrow-derived lymphocytes. Synthesis, surface deposition, turnover and carbohydrate composition in unstimulated mouse B cells.骨髓来源淋巴细胞中的IgM。未刺激的小鼠B细胞中的合成、表面沉积、周转及碳水化合物组成。
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Lymphocyte binding of aggregated IgG and surface Ig staining in chronic lymphocytic leukaemia.慢性淋巴细胞白血病中聚集IgG的淋巴细胞结合及表面Ig染色
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