大鼠肥大细胞系在有丝分裂期间，组胺的刺激释放受到抑制。
Stimulated release of histamine by a rat mast cell line is inhibited during mitosis.
作者信息
Hesketh T R, Beaven M A, Rogers J, Burke B, Warren G B
出版信息
J Cell Biol. 1984 Jun;98(6):2250-4. doi: 10.1083/jcb.98.6.2250.
Abstract
Stimulated histamine release was depressed at least tenfold in mitotic 2H3 rat basophilic cells when compared with interphase cells even though both contained comparable amounts of histamine. Antigen stimulation of IgE-sensitized interphase cells initiated an influx of Ca2+ that preceded secretion of histamine and a similar Ca2+ influx occurred in stimulated mitotic cells. This strongly suggests that during mitosis there is a dramatic inhibition of one or more of the steps on the pathway leading from elevated intracellular Ca2+ to the fusion of secretory granules with the plasma membrane.
摘要
与间期细胞相比，有丝分裂期的2H3大鼠嗜碱性细胞中，即使两者组胺含量相当，但刺激后的组胺释放至少降低了10倍。抗原刺激IgE致敏的间期细胞会引发组胺分泌前的Ca2+内流，刺激有丝分裂期细胞时也会发生类似的Ca2+内流。这有力地表明，在有丝分裂期间，从细胞内Ca2+升高到分泌颗粒与质膜融合的信号通路中，一个或多个步骤受到了显著抑制。
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