单纯疱疹病毒感染的抗独特型调节导致致病性增加。
Antiidiotype modulation of herpes simplex virus infection leading to increased pathogenicity.
作者信息
Kennedy R C, Adler-Storthz K, Burns J W, Henkel R D, Dreesman G R
出版信息
J Virol. 1984 Jun;50(3):951-3. doi: 10.1128/JVI.50.3.951-953.1984.
Abstract
Antiidiotype reagents that recognize idiotypic determinants associated with the combining site of monoclonal antibodies to herpes simplex virus type 2 ( HSV2 ) were used to manipulate the immune response to HSV2 in BALB/c mice. The injection of antiidiotype antibodies into mice before challenge with a 50% lethal dose of HSV2 resulted in a shorter survival time than that of mice receiving either preimmune rabbit immunoglobulin G or antiidiotype reagents against hepatitis B surface antigen before HSV2 challenge. These findings indicate that the immune response to HSV2 in mice can be modulated through idiotype- antiidiotype networks, thereby increasing the pathogenicity of HSV2 infections.
摘要
利用抗独特型试剂识别与单纯疱疹病毒2型（HSV2）单克隆抗体结合位点相关的独特型决定簇，来调控BALB/c小鼠对HSV2的免疫反应。在用50%致死剂量的HSV2攻击小鼠之前给其注射抗独特型抗体，结果显示其存活时间比在HSV2攻击前接受免疫前兔免疫球蛋白G或抗乙型肝炎表面抗原抗独特型试剂的小鼠更短。这些发现表明，小鼠对HSV2的免疫反应可通过独特型-抗独特型网络进行调节，从而增加HSV2感染的致病性。
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