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Immune response to bovine viral diarrhea virus induced by anti-idiotypic antibodies.

作者信息

Xue W, Minocha H C

机构信息

Department of Pathology and Microbiology, College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA.

出版信息

Clin Diagn Lab Immunol. 1994 Jan;1(1):95-8. doi: 10.1128/cdli.1.1.95-98.1994.

DOI:10.1128/cdli.1.1.95-98.1994
PMID:7496930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC368203/
Abstract

We have previously prepared rabbit anti-idiotypic antibodies (anti-Ids) against the neutralizing monoclonal antibodies (MAbs) specific for the gp53 of bovine viral diarrhea virus (BVDV). The anti-Ids, purified by sequential immunoaffinity chromatography, inhibited the immunizing MAb from binding to the original antigens and blocked BVDV infection of cell cultures. This study evaluated immune responses in mice to the purified anti-Id reagents. BVDV-specific neutralizing antibodies were induced by the anti-Ids. The antisera (Ab3) induced by the anti-Ids immunoprecipitated gp53 from BVDV-infected Madin-Darby bovine kidney (MDBK) cell lysates. However, lymphocyte-proliferative responses were specific only for the respective immunizing antigens. These results suggest that the anti-Ids may bear an internal image of the gp53 to stimulate production of antibody but not to stimulate a virus-specific cellular immune response in mice.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0bb/368203/f0ce9d49a622/cdli00001-0119-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0bb/368203/f0ce9d49a622/cdli00001-0119-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0bb/368203/f0ce9d49a622/cdli00001-0119-a.jpg

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引用本文的文献

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本文引用的文献

1
Production of Plaques in Monolayer Tissue Cultures by Single Particles of an Animal Virus.动物病毒单颗粒在单层组织培养物中产生噬斑
Proc Natl Acad Sci U S A. 1952 Aug;38(8):747-52. doi: 10.1073/pnas.38.8.747.
2
Anti-idiotypic antibodies induce neutralizing antibodies to rabies virus glycoprotein.抗独特型抗体可诱导产生针对狂犬病病毒糖蛋白的中和抗体。
J Virol. 1983 Dec;48(3):660-6. doi: 10.1128/JVI.48.3.660-666.1983.
3
Syngeneic monoclonal antiidiotype can induce cellular immunity to reovirus.同基因单克隆抗独特型抗体可诱导对呼肠孤病毒的细胞免疫。
J Exp Med. 1984 Oct 1;160(4):1195-205. doi: 10.1084/jem.160.4.1195.
4
Suppression of neutrophil and lymphocyte function induced by a vaccinal strain of bovine viral diarrhea virus with and without the administration of ACTH.牛病毒性腹泻病毒疫苗株诱导的中性粒细胞和淋巴细胞功能抑制，无论是否给予促肾上腺皮质激素。
Am J Vet Res. 1983 Dec;44(12):2366-72.
5
Antiidiotype modulation of herpes simplex virus infection leading to increased pathogenicity.单纯疱疹病毒感染的抗独特型调节导致致病性增加。
J Virol. 1984 Jun;50(3):951-3. doi: 10.1128/JVI.50.3.951-953.1984.
6
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
7
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
8
Immune response to human immunodeficiency virus. In vivo administration of anti-idiotype induces an anti-gp160 response specific for a synthetic peptide.对人类免疫缺陷病毒的免疫反应。抗独特型抗体的体内给药诱导出针对合成肽的抗gp160反应。
J Immunol. 1987 Nov 1;139(9):2950-6.
9
Production, binding characteristics, and immunogenicity of heterologous anti-idiotypic antibody to herpes simplex virus glycoprotein C.
Viral Immunol. 1987 Spring;1(1):13-23. doi: 10.1089/vim.1987.1.13.
10
Anti-idiotypes and immunity.
Sci Am. 1986 Jul;255(1):48-56. doi: 10.1038/scientificamerican0786-48.