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哮喘患者体内源自单核细胞的组胺释放因子（HRF）。体外嗜碱性粒细胞释放组胺。

A mononuclear cell derived histamine releasing factor (HRF) in asthmatic patients. Histamine release from basophils in vitro.

作者信息

Alam R, Rozniecki J, Salmaj K

出版信息

Ann Allergy. 1984 Jul;53(1):66-9.

PMID:6204562
Abstract

Mononuclear cells from asthmatic patients produced a histamine releasing factor (HRF). Mononuclear cells produced this factor in culture spontaneously but significantly much more following specific allergen stimulation. This factor released histamine from both sensitized and unsensitized basophils in vitro. Mononuclear cells from healthy subjects produced HRF only after nonspecific mitogen/phytohemagglutinin stimulation. Asthmatic patients on immunotherapy with essential benefits failed to produce HRF.

摘要

哮喘患者的单核细胞产生一种组胺释放因子（HRF）。单核细胞在培养中可自发产生该因子，但在特异性变应原刺激后产生的量显著更多。该因子在体外可从致敏和未致敏的嗜碱性粒细胞中释放组胺。健康受试者的单核细胞仅在非特异性有丝分裂原/植物血凝素刺激后才产生HRF。接受免疫疗法且有显著疗效的哮喘患者未能产生HRF。

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Ann Allergy. 1984 Jul;53(1):66-9.
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The release of eosinophil chemotactic activity and eosinophil chemokinesis inhibitory activity by mononuclear cells from atopic asthmatic and non-atopic subjects.
特应性哮喘患者和非特应性受试者的单核细胞释放嗜酸性粒细胞趋化活性和嗜酸性粒细胞趋化抑制活性。
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