Stephens S, Kennedy C R, Lakhani P K, Brenner M K
Acta Paediatr Scand. 1984 Jul;73(4):426-32. doi: 10.1111/j.1651-2227.1984.tb09950.x.
The effects of breast- and bottle-feeding on serum immunoglobulin levels and specific antibody responses have been examined in 30 infants on five occasions from 6 days until 9 months of age. No significant differences were found on any sample occasion between the two feeding groups in total immunoglobulin levels of G, M and A classes or in class-specific antibody responses to tetanus toxoid vaccine. This suggests that the capacity of the two groups to make serum antibodies develops similarly. Concentrations of antibodies to commensal Escherichia coli 'O' lipopolysaccharide antigens, however, were significantly greater in the bottle-fed group, and it is suggested that this difference is due to an increase in the exposure of the systemic immune system to these gut antigens in the bottle-fed infants. There are several possible explanations for this increased exposure and the resulting effects on the infants' immune system. These experiments also illustrate a possible role of breast milk in stimulating the immune system.
对30名婴儿从6天大到9个月大期间进行了5次检查，以研究母乳喂养和奶瓶喂养对血清免疫球蛋白水平及特异性抗体反应的影响。在任何一个采样时间点，两个喂养组在G、M和A类总免疫球蛋白水平或对破伤风类毒素疫苗的类特异性抗体反应方面均未发现显著差异。这表明两组产生血清抗体的能力发展相似。然而，奶瓶喂养组中针对共生大肠杆菌“O”脂多糖抗原的抗体浓度显著更高，据推测，这种差异是由于奶瓶喂养婴儿的全身免疫系统对这些肠道抗原的接触增加所致。对于这种接触增加及其对婴儿免疫系统产生的影响，有几种可能的解释。这些实验还说明了母乳在刺激免疫系统方面可能发挥的作用。
