Iqbal M J, Wilkinson M L, Williams R
Br Med J (Clin Res Ed). 1984 Aug 25;289(6443):459-60. doi: 10.1136/bmj.289.6443.459.
Owing to recent findings of certain unusual sex steroid binding in liver disease--particularly an allosteric biphasic pattern (pattern A) unique to the serum of patients with hepatocellular carcinoma--the serum binding characteristics for 5 alpha-dihydrotestosterone were examined in serum samples from six patients with primary biliary cirrhosis who had developed hepatocellular carcinoma. In all serum samples taken after the development of tumour pattern A binding only was obtained, and in four cases in which earlier samples were also examined there was a transformation from the normal, non-specific binding pattern, or an allosteric plateau pattern seen in non-malignant liver disease (designated D and C respectively), to pattern A coincident with the rise in serum alpha fetoprotein. In one patient chemotherapy leading to a fall in alpha fetoprotein abolished pattern A binding, showing further its close association with tumour growth. The value of pattern A binding as a tumour marker in hepatocellular carcinoma warrants further study.
由于最近在肝脏疾病中发现了某些异常的性类固醇结合现象——特别是肝细胞癌患者血清特有的变构双相模式（模式A）——我们检测了6例已发展为肝细胞癌的原发性胆汁性肝硬化患者血清样本中5α-双氢睾酮的血清结合特征。在肿瘤发生后采集的所有血清样本中，仅获得了模式A结合，在4例也检测了早期样本的病例中，出现了从正常的非特异性结合模式，或在非恶性肝脏疾病中所见的变构平台模式（分别称为D和C），转变为与血清甲胎蛋白升高同时出现的模式A。在1例接受化疗导致甲胎蛋白下降的患者中，模式A结合消失，进一步表明其与肿瘤生长密切相关。模式A结合作为肝细胞癌肿瘤标志物的价值值得进一步研究。
