Hirschman S Z
Science. 1971 Jul 30;173(3995):441-3. doi: 10.1126/science.173.3995.441.
Ethidium bromide, compared on a molar basis, was a more effective inhibitor of the DNA polymerases of the Rauscher and Moloney murine leukemia viruses than either 4-N-demethylrifampicin or 4-N-benzyldemethylrifampicin. Daunomycin inhibited the polymerases weakly, and chromomycin A(3) inhibited almost not at all. 4-N-Benzyldemethylrifampicin was a more active inhibitor than the 4-N-demethyl congener.
在摩尔基础上进行比较，溴化乙锭比4-N-去甲基利福平或4-N-苄基去甲基利福平更有效地抑制劳氏肉瘤病毒和莫洛尼氏鼠白血病病毒的DNA聚合酶。柔红霉素对聚合酶的抑制作用较弱，而放线菌素A(3)几乎没有抑制作用。4-N-苄基去甲基利福平是比4-N-去甲基类似物更具活性的抑制剂。
