• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人类骨骼肌α-肌动蛋白信使核糖核酸的3'非翻译序列。

The 3'-untranslated sequence of human skeletal muscle alpha-actin mRNA.

作者信息

Gillespie G, Lloyd J, Hopkinson D, Edwards Y

出版信息

J Muscle Res Cell Motil. 1984 Aug;5(4):457-64. doi: 10.1007/BF00818263.

DOI:10.1007/BF00818263
PMID:6207203
Abstract

A human actin cDNA clone pGF3 isolated from a fetal skeletal muscle cDNA library is described. The insert cDNA is homologous to skeletal muscle alpha-actin as judged by restriction mapping and nucleotide sequencing. The recombinant contains a substantial portion of the coding and the complete 3'-untranslated region. Comparison of the 3' ends of human and rat skeletal muscle and human cardiac alpha-actins reveals little homology between different types of actin genes in man but marked conservation of this region in the skeletal muscle actins of man and rat.

摘要

本文描述了从胎儿骨骼肌cDNA文库中分离得到的一个人类肌动蛋白cDNA克隆pGF3。通过限制性图谱分析和核苷酸测序判断，插入的cDNA与骨骼肌α-肌动蛋白同源。该重组体包含编码区的大部分以及完整的3'非翻译区。对人类和大鼠骨骼肌以及人类心脏α-肌动蛋白3'末端的比较显示，人类不同类型的肌动蛋白基因之间同源性较低，但该区域在人类和大鼠的骨骼肌肌动蛋白中具有显著的保守性。

相似文献

1
The 3'-untranslated sequence of human skeletal muscle alpha-actin mRNA.人类骨骼肌α-肌动蛋白信使核糖核酸的3'非翻译序列。
J Muscle Res Cell Motil. 1984 Aug;5(4):457-64. doi: 10.1007/BF00818263.
2
Isolation and characterization of cDNA clones for human skeletal muscle alpha actin.人骨骼肌α-肌动蛋白cDNA克隆的分离与鉴定
Nucleic Acids Res. 1983 Jun 11;11(11):3503-16. doi: 10.1093/nar/11.11.3503.
3
The structure of a cDNA clone corresponding to mouse cardiac muscle actin mRNA.与小鼠心肌肌动蛋白mRNA对应的cDNA克隆的结构。
Biosci Rep. 1986 Aug;6(8):741-7. doi: 10.1007/BF01116542.
4
Expression of the genes coding for the skeletal muscle and cardiac actions in the heart.编码骨骼肌和心脏活动的基因在心脏中的表达。
Nucleic Acids Res. 1984 Jan 25;12(2):1087-100. doi: 10.1093/nar/12.2.1087.
5
Isolation and characterization of cDNA clones from mouse skeletal muscle actin mRNA.从小鼠骨骼肌肌动蛋白信使核糖核酸中分离并鉴定互补脱氧核糖核酸克隆
DNA. 1986 Jun;5(3):235-8. doi: 10.1089/dna.1986.5.235.
6
Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed.人α-、β-和γ-肌动蛋白mRNA全长cDNA克隆的分离与鉴定：骨骼肌肌动蛋白而非细胞质肌动蛋白具有一个随后会被去除的氨基端半胱氨酸。
Mol Cell Biol. 1983 May;3(5):787-95. doi: 10.1128/mcb.3.5.787-795.1983.
7
Molecular cloning of seal myoglobin mRNA.海豹肌红蛋白mRNA的分子克隆
Nucleic Acids Res. 1982 Nov 25;10(22):7133-44. doi: 10.1093/nar/10.22.7133.
8
Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA.肌动蛋白mRNA非翻译区的进化保守性：人β-肌动蛋白cDNA的DNA序列
Nucleic Acids Res. 1984 Feb 10;12(3):1687-96. doi: 10.1093/nar/12.3.1687.
9
Skeletal muscle actin mRNA. Characterization of the 3' untranslated region.骨骼肌肌动蛋白信使核糖核酸。3'非翻译区的特征
Nucleic Acids Res. 1981 Feb 11;9(3):579-89. doi: 10.1093/nar/9.3.579.
10
Mouse actin messenger RNAs. Construction and characterization of a recombinant plasmid molecule containing a complementary DNA transcript of mouse alpha-actin mRNA.小鼠肌动蛋白信使核糖核酸。含有小鼠α-肌动蛋白信使核糖核酸互补脱氧核糖核酸转录物的重组质粒分子的构建与特性分析。
J Biol Chem. 1981 Jan 25;256(2):1008-14.

引用本文的文献

1
Highly conserved sequences in the 3' untranslated region of mRNAs coding for homologous proteins in distantly related species.远缘物种中编码同源蛋白质的mRNA的3'非翻译区的高度保守序列。
Nucleic Acids Res. 1985 May 24;13(10):3723-37. doi: 10.1093/nar/13.10.3723.
2
Human glyceraldehyde-3-phosphate dehydrogenase: mRNA levels and enzyme activity in developing muscle.人甘油醛-3-磷酸脱氢酶：发育中肌肉中的mRNA水平和酶活性
Mol Cell Biol. 1985 Aug;5(8):2147-9. doi: 10.1128/mcb.5.8.2147-2149.1985.
3
Mouse carbonic anhydrase III: nucleotide sequence and expression studies.

本文引用的文献

1
The genes coding for the muscle contractile proteins, myosin heavy chain, myosin light chain 2, and skeletal muscle actin are located on three different mouse chromosomes.编码肌肉收缩蛋白、肌球蛋白重链、肌球蛋白轻链2和骨骼肌肌动蛋白的基因位于三条不同的小鼠染色体上。
EMBO J. 1982;1(11):1299-305. doi: 10.1002/j.1460-2075.1982.tb01314.x.
2
A fetal skeletal muscle actin mRNA in the mouse and its identity with cardiac actin mRNA.小鼠胎儿骨骼肌肌动蛋白信使核糖核酸及其与心肌肌动蛋白信使核糖核酸的一致性
Cell. 1982 Aug;30(1):185-92. doi: 10.1016/0092-8674(82)90024-1.
3
Skeletal muscle actin mRNA. Characterization of the 3' untranslated region.
小鼠碳酸酐酶III：核苷酸序列与表达研究。
Biochem Genet. 1989 Feb;27(1-2):17-30. doi: 10.1007/BF00563015.
4
Induction of carbonic anhydrase III mRNA and protein by denervation of rat muscle.大鼠肌肉去神经支配诱导碳酸酐酶III信使核糖核酸和蛋白质的产生。
Biochem J. 1988 Nov 15;256(1):147-52. doi: 10.1042/bj2560147.
5
Tissue distribution of the dystrophin-related gene product and expression in the mdx and dy mouse.肌营养不良蛋白相关基因产物的组织分布及在mdx和dy小鼠中的表达
Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3243-7. doi: 10.1073/pnas.88.8.3243.
6
Phosphoglucomutase 1: complete human and rabbit mRNA sequences and direct mapping of this highly polymorphic marker on human chromosome 1.磷酸葡萄糖变位酶1：完整的人类和兔mRNA序列以及该高度多态性标记在人类1号染色体上的直接定位
Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):411-5. doi: 10.1073/pnas.89.1.411.
骨骼肌肌动蛋白信使核糖核酸。3'非翻译区的特征
Nucleic Acids Res. 1981 Feb 11;9(3):579-89. doi: 10.1093/nar/9.3.579.
4
Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes.使用特异性克隆的cDNA探针检测α-和β-微管蛋白以及细胞质β-和γ-肌动蛋白基因的数量和进化保守性。
Cell. 1980 May;20(1):95-105. doi: 10.1016/0092-8674(80)90238-x.
5
Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed.人α-、β-和γ-肌动蛋白mRNA全长cDNA克隆的分离与鉴定：骨骼肌肌动蛋白而非细胞质肌动蛋白具有一个随后会被去除的氨基端半胱氨酸。
Mol Cell Biol. 1983 May;3(5):787-95. doi: 10.1128/mcb.3.5.787-795.1983.
6
Strong homology in promoter and 3'-untranslated regions of chick and rat alpha-actin genes.鸡和大鼠α-肌动蛋白基因启动子及3'非翻译区的高度同源性。
Nature. 1983 May 26;303(5915):348-9. doi: 10.1038/303348a0.
7
The scattered distribution of actin genes in the mouse and human genomes.肌动蛋白基因在小鼠和人类基因组中的分散分布。
EMBO J. 1982;1(5):579-83. doi: 10.1002/j.1460-2075.1982.tb01211.x.
8
Molecular structure and evolutionary origin of human cardiac muscle actin gene.人类心肌肌动蛋白基因的分子结构与进化起源
Proc Natl Acad Sci U S A. 1982 Oct;79(19):5901-5. doi: 10.1073/pnas.79.19.5901.
9
Number and organization of actin-related sequences in the mouse genome.小鼠基因组中肌动蛋白相关序列的数量与组织
J Mol Biol. 1983 Jun 15;167(1):77-101. doi: 10.1016/s0022-2836(83)80035-7.
10
The nucleotide sequence of the rat cytoplasmic beta-actin gene.大鼠细胞质β-肌动蛋白基因的核苷酸序列。
Nucleic Acids Res. 1983 Mar 25;11(6):1759-71. doi: 10.1093/nar/11.6.1759.