5-hydroxytryptamine induced changes in body temperature of newborn kittens and guinea-pigs and the effect of indomethacin thereon.

During the first days of life 10 microgram i.c.v. 5-HT evoked a primary, short-lasting hyperthermia in kittens and hypothermia in guinea-pigs. In both species, a secondary late hyperthermia occurred that could be prevented by indomethacin pretreatment.