Juhlin L, Rollman O
Acta Derm Venereol. 1984;64(5):439-40.
An anesthetic cream with an eutectic mixture of 5% lidocaine and 5% prilocaine has been tested on the skin of healthy subjects and patients with atopic dermatitis and generalized eczema. In healthy subjects a blanching was seen when the analgesia was complete after 30-60 min. In the dry skin and eczematous lesions of atopic dermatitis an application time of 5-15 min caused a blanching and a good analgesia. When applied for 30-60 min the eczematous skin became increasingly red and in one patient purpura appeared. The white dermographism turned red in treated areas. The abnormal vascular reactions to the cream in diseased skin can be explained by a rapid and increased percutaneous absorption of the anesthetics. A shortened application time is here recommended.
一种含有5%利多卡因和5%丙胺卡因共晶混合物的麻醉乳膏已在健康受试者以及特应性皮炎和泛发性湿疹患者的皮肤上进行了测试。在健康受试者中，30 - 60分钟后镇痛完全时可见皮肤变白。在特应性皮炎的干性皮肤和湿疹性皮损处，涂抹5 - 15分钟会导致皮肤变白且镇痛效果良好。涂抹30 - 60分钟后，湿疹皮肤会变得越来越红，有一名患者出现了紫癜。治疗区域的白色皮肤划痕症变红。患病皮肤对该乳膏的异常血管反应可通过麻醉剂经皮快速且增加的吸收来解释。在此建议缩短涂抹时间。
