Furuse A, Hattori S, Terashima T, Karashima S, Matsuda I
Nephron. 1982;31(3):212-8. doi: 10.1159/000182649.
Urinary abnormalities combined with positive serum hepatitis B virus surface antigen (HBsAg) were found in 9 children. Most of these patients were found by mass urine screening of school children. Renal biopsy findings revealed 6 cases of membranous glomerulonephropathy (MGN) and 3 cases of minimal change disease. Immune deposits consisting of hepatitis B virus e antigen (HBeAg), IgG and C3 were detected in the glomerular capillary walls by immunofluorescent study in patients with MGN. Circulating immune complex was positive at a rate of 67% (6/9 cases) by the C1q-binding assay and at a rate of 56% (5/9 cases) by the protein-A precipitation test in patients with persistent urinary abnormalities and hepatic dysfunction.
9名儿童被发现存在泌尿系统异常并伴有血清乙肝表面抗原（HBsAg）阳性。这些患者大多是在对学童进行大规模尿液筛查时被发现的。肾活检结果显示，6例为膜性肾小球肾病（MGN），3例为微小病变病。通过免疫荧光研究，在MGN患者的肾小球毛细血管壁中检测到由乙肝e抗原（HBeAg）、IgG和C3组成的免疫沉积物。持续性泌尿系统异常和肝功能障碍患者中，通过C1q结合试验检测循环免疫复合物阳性率为67%（6/9例），通过蛋白A沉淀试验检测阳性率为56%（5/9例）。
