蛋白质合成抑制剂对腺病毒2型感染早期合成的病毒信使核糖核酸的影响。
Effect of protein synthesis inhibitors on viral mRNA's synthesized early in adenovirus type 2 infection.
作者信息
Eggerding F, Raskas H J
出版信息
J Virol. 1978 Jan;25(1):453-8. doi: 10.1128/JVI.25.1.453-458.1978.
Abstract
Viral mRNA species synthesized early in adenovirus type 2 infection in the presence of cycloheximide were compared with those synthesized in the absence of drug or in the presence of the DNA synthesis inhibitor 1-beta-D-arabinofuranosylcytosine. Cycloheximide caused approximately a 10-fold stimulation in the accumulation of [3H]uridine into early viral mRNA species. The only exception was a 24s mRNA transcribed from the transforming end of the genome; in the presence of cycloheximide, accumulation of this mRNA species was stimulated no more than 2-fold. Treatment with cycloheximide also resulted in the accumulation of polyadenylated RNAs transcribed from EcoRI-C that are heterogeneous and smaller than the 20S mRNA. Other translation inhibitors were shown to have similar effects, suggesting that inhibition of protein synthesis early after infection induces alterations in the metabolism of specific RNA sequences.
摘要
将在2型腺病毒感染早期、存在放线菌酮的情况下合成的病毒mRNA种类，与在无药物存在或存在DNA合成抑制剂1-β-D-阿拉伯呋喃糖基胞嘧啶的情况下合成的病毒mRNA种类进行了比较。放线菌酮使[3H]尿苷积累到早期病毒mRNA种类中的量增加了约10倍。唯一的例外是从基因组转化末端转录的24s mRNA；在放线菌酮存在的情况下，这种mRNA种类的积累仅增加了2倍。用放线菌酮处理还导致从EcoRI-C转录的多聚腺苷酸化RNA的积累，这些RNA是异质的，且比20S mRNA小。其他翻译抑制剂也显示出类似的效果，这表明感染后早期蛋白质合成的抑制会诱导特定RNA序列代谢的改变。
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