Davies B H, Williams J D, Smith M D, Jones-Williams W, Jones K
Pathol Res Pract. 1982 Oct;175(1):97-109. doi: 10.1016/S0344-0338(82)80045-9.
Sarcoidosis is characterised by changes in the lymphocyte subpopulations of the peripheral venous blood in the majority of patients. Thymus derived lymphocytes (T cells) are low whilst Bursa derived lymphocytes (B cells) are usually normal in number. The T cell lymphopaenia is best regarded as a "switching off" of available receptors as in vitro treatment with Levamisole restores this population to normal control values. A functional subset of T cells, T suppressor cells (T gamma) are activated, in sarcoidosis, in peripheral venous blood. Sarcoid sera is characterised by two inhibiting fractions; one, of low molecular weight (60 000 daltons) inhibits E rosette formation by normal T lymphocytes and may be a product of T suppressor cells or epithelioid/macrophage cells: the other is an immune complex which is capable of activating normal T suppressor cells and the serum immune complex concentration is positively correlated with suppressor cell activation in sarcoidosis.
在大多数患者中，结节病的特征是外周静脉血中淋巴细胞亚群发生变化。胸腺来源的淋巴细胞（T细胞）数量减少，而法氏囊来源的淋巴细胞（B细胞）数量通常正常。T细胞淋巴细胞减少最好被视为可用受体的“关闭”，因为用左旋咪唑进行体外治疗可使该群体恢复到正常对照值。在结节病中，外周静脉血中T细胞的一个功能亚群，即T抑制细胞（Tγ）被激活。结节病血清的特征在于两个抑制组分；一种低分子量（60000道尔顿）的组分可抑制正常T淋巴细胞形成E玫瑰花结，可能是T抑制细胞或上皮样/巨噬细胞的产物：另一种是免疫复合物，能够激活正常T抑制细胞，并且血清免疫复合物浓度与结节病中抑制细胞的激活呈正相关。
