Miller G, Martin K, Katz B Z, Andiman W A
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06510.
Yale J Biol Med. 1987 Nov-Dec;60(6):527-35.
As of December 1986, we have identified 23 symptomatic children with human immunodeficiency virus (HIV) infection in New Haven. Twelve developed AIDS as manifested by lymphocytic interstitial pneumonitis, Pneumocystis carinii pneumonia (PCP), and/or disseminated mycobacterial infections; seven of them have died. The remainder have milder clinical syndromes, which include failure to thrive, diffuse lymphadenopathy, and parotid swelling. When compared to adults with AIDS, children often have hypergammaglobulinemia and normal numbers of T4 lymphocytes. Intravenous drug abuse by the mother or mother's consort is the risk factor in 87 percent of these children. Two families have now been identified with more than one symptomatic child, but in no family is there evidence of spread from symptomatic children to uninfected siblings. A prospective study was begun to attempt to assess the risk of developing symptomatic HIV infection when a child is born to a mother with antibodies to HIV.
截至1986年12月，我们在纽黑文已确认有23名出现症状的儿童感染了人类免疫缺陷病毒（HIV）。其中12名发展为艾滋病，表现为淋巴细胞间质性肺炎、卡氏肺孢子虫肺炎（PCP）和/或播散性分枝杆菌感染；他们中有7人已经死亡。其余儿童有较轻微的临床综合征，包括发育不良、弥漫性淋巴结病和腮腺肿大。与患艾滋病的成人相比，儿童常有高球蛋白血症且T4淋巴细胞数量正常。这些儿童中有87%的危险因素是母亲或其配偶静脉注射毒品。现已确认有两个家庭有不止一名出现症状的儿童，但没有一个家庭有证据表明症状性儿童将病毒传播给未受感染的兄弟姐妹。一项前瞻性研究已经开始，试图评估母亲有HIV抗体时孩子出生后出现症状性HIV感染的风险。
