肽树状大分子和多黏菌素 B 的抗菌活性在 pH 值高于 7.4 时急剧增加。

Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland.

Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.

Chem Commun (Camb). 2021 Jun 8;57(46):5654-5657. doi: 10.1039/d1cc01838h.

pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar effect occurs with polymyxin B and might be general for polycationic antimicrobials.

pH 活性分析表明，抗菌肽树状大分子（AMPDs）在 pH = 8.0 时可以杀死肺炎克雷伯菌和耐甲氧西林金黄色葡萄球菌（MRSA），而在 pH = 7.4 时则没有活性，这是因为在较高 pH 值下，它们与细菌细胞的静电结合更强。多粘菌素 B 也会产生类似的效果，这种效果可能普遍存在于多阳离子抗菌剂中。