Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland.
Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.
Chem Commun (Camb). 2021 Jun 8;57(46):5654-5657. doi: 10.1039/d1cc01838h.
pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar effect occurs with polymyxin B and might be general for polycationic antimicrobials.
pH 活性分析表明，抗菌肽树状大分子（AMPDs）在 pH = 8.0 时可以杀死肺炎克雷伯菌和耐甲氧西林金黄色葡萄球菌（MRSA），而在 pH = 7.4 时则没有活性，这是因为在较高 pH 值下，它们与细菌细胞的静电结合更强。多粘菌素 B 也会产生类似的效果，这种效果可能普遍存在于多阳离子抗菌剂中。
