Pallanza R, Berti M, Goldstein B P, Mapelli E, Randisi E, Scotti R, Arioli V
J Antimicrob Chemother. 1983 May;11(5):419-25. doi: 10.1093/jac/11.5.419.
Teichomycin, a new glycopeptide antibiotic with a spectrum of activity similar to that of vancomycin, was highly active against staphylococci, streptococci and Gram-positive anaerobes (Propionibacterium acnes, Clostridium perfringens and Cl. difficile). Ninety per cent of the Staphylococcus aureus and streptococcal strains, including enterococci, were inhibited by 0.4 mg/l; 90% of Staph. epidermidis strains were susceptible to 1.6 mg/l. Vancomycin was less active than teichomycin against all clinical isolates tested. Multiply resistant strains, including methicillin-resistant Staph. aureus, were all susceptible to teichomycin and vancomycin. Teichomycin was highly bactericidal for growing cells of staphylococci and Streptococcus pyogenes and moderately bactericidal for Str. faecalis. In mice, teichomycin was well absorbed upon subcutaneous administration and had a half-life of 2.5 h. It was very effective in curing experimental mouse septicemias caused by Gram-positive bacteria (ED50 values less than 1 mg/kg).
替考拉宁是一种新型糖肽类抗生素，其抗菌谱与万古霉素相似，对葡萄球菌、链球菌及革兰氏阳性厌氧菌（痤疮丙酸杆菌、产气荚膜梭菌和艰难梭菌）具有高度活性。包括肠球菌在内的90%的金黄色葡萄球菌和链球菌菌株可被0.4mg/L的替考拉宁抑制；90%的表皮葡萄球菌菌株对1.6mg/L的替考拉宁敏感。在所有测试的临床分离株中，万古霉素的活性低于替考拉宁。包括耐甲氧西林金黄色葡萄球菌在内的多重耐药菌株对替考拉宁和万古霉素均敏感。替考拉宁对葡萄球菌和化脓性链球菌的生长细胞具有高度杀菌作用，对粪肠球菌具有中度杀菌作用。在小鼠中，替考拉宁皮下给药后吸收良好，半衰期为2.5小时。它对治疗由革兰氏阳性菌引起的实验性小鼠败血症非常有效（半数有效剂量值小于1mg/kg）。
