Varaldo P E, Debbia E, Schito G C
Antimicrob Agents Chemother. 1983 Mar;23(3):402-6. doi: 10.1128/AAC.23.3.402.
The antibacterial activity of teichomycin, a glycopeptide antibiotic similar to vancomycin, has been evaluated in vitro and compared with that of vancomycin. Test strains included 130 staphylococci and 132 streptococci, with representatives of the major currently recognized species or groups, and lesser numbers of clostridia, propionibacteria, and group JK bacteria. Teichomycin was found to be more active than vancomycin. Its minimum inhibitory concentration (MIC) was two- to fourfold lower than that of vancomycin with staphylococci and anaerobic bacteria, and two- to eightfold lower with streptococci. No significant differences were observed with group JK bacteria. For most strains tested, minimum bactericidal concentrations (MBCs) of both teichomycin and vancomycin either equalled or exceeded by twofold the respective MICs. Higher MBC-to-MIC ratios were obtained for enterococci and pneumococci with both antibiotics. Both teichomycin and vancomycin showed similar in vitro interactions with rifampin in combination tests. Neither antagonism nor (with very few exceptions) synergism occurred.
替考拉宁是一种与万古霉素类似的糖肽类抗生素，其抗菌活性已在体外进行评估，并与万古霉素进行了比较。测试菌株包括130株葡萄球菌和132株链球菌，涵盖了目前主要认可的菌种或菌群的代表，以及少量的梭菌、丙酸杆菌和JK群细菌。结果发现替考拉宁比万古霉素更具活性。其最低抑菌浓度（MIC）比万古霉素低两到四倍，对葡萄球菌和厌氧菌是这样，对链球菌则低两到八倍。JK群细菌未观察到显著差异。对于大多数测试菌株，替考拉宁和万古霉素的最低杀菌浓度（MBC）要么等于各自的MIC，要么超过两倍。两种抗生素对肠球菌和肺炎球菌的MBC与MIC比值更高。在联合试验中，替考拉宁和万古霉素与利福平在体外的相互作用相似。既未出现拮抗作用，也未出现（极少数例外情况除外）协同作用。
