替考拉宁与万古霉素单独及联合利福平、氨基糖苷类药物对葡萄球菌和肠球菌的体外比较活性
Comparative in vitro activities of teichomycin and vancomycin alone and in combination with rifampin and aminoglycosides against staphylococci and enterococci.
作者信息
Tuazon C U, Miller H
出版信息
Antimicrob Agents Chemother. 1984 Apr;25(4):411-2. doi: 10.1128/AAC.25.4.411.
Abstract
The activity of teichomycin A2 was compared with that of vancomycin in vitro against clinical isolates of staphylococci and enterococci. Teichomycin A2 was more active than vancomycin active against all isolates tested. Synergistic studies also demonstrated that teichomycin A2 combined with rifampin is more active than vancomycin combined with rifampin against Staphylococcus aureus and Staphylococcus epidermidis isolates. Teichomycin A2, either singly or in combination with an aminoglycoside, was more active against Streptococcus faecalis isolates.
摘要
在体外，将替考拉宁A2与万古霉素针对葡萄球菌和肠球菌的临床分离株的活性进行了比较。替考拉宁A2对所有测试的分离株的活性均高于万古霉素。协同研究还表明，替考拉宁A2与利福平联合使用时，针对金黄色葡萄球菌和表皮葡萄球菌分离株的活性高于万古霉素与利福平联合使用时。替考拉宁A2单独使用或与氨基糖苷类联合使用时，对粪肠球菌分离株的活性更高。
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