登革病毒诱导的抑制途径中T淋巴细胞对环磷酰胺的敏感性差异
Differential cyclophosphamide sensitivity of T lymphocytes of the dengue virus-induced suppressor pathway.
作者信息
Shukla M I, Chaturvedi U C
出版信息
Br J Exp Pathol. 1984 Aug;65(4):397-403.
Abstract
Dengue type 2 virus (DV) induces a suppressor pathway in mice which involves sequential participation of three subpopulations of T lymphocytes viz. Ts1, Ts2 and T3 cells. In the present study cyclophosphamide (CY) sensitivity of these cells have been investigated. The findings of the present study demonstrate that Ts1 and Ts2 cells are CY-insensitive while T3 cells are CY-sensitive. This supports our earlier conclusion that T3 may be the inducer cells of suppression.
摘要
登革2型病毒（DV）在小鼠中诱导一种抑制途径，该途径涉及三个T淋巴细胞亚群，即Ts1、Ts2和T3细胞的顺序参与。在本研究中，已对这些细胞的环磷酰胺（CY）敏感性进行了研究。本研究结果表明，Ts1和Ts2细胞对CY不敏感，而T3细胞对CY敏感。这支持了我们早期的结论，即T3可能是抑制的诱导细胞。
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Transmission of dengue virus-induced suppressor signal from macrophage to lymphocyte occurs by cell contact.登革病毒诱导的抑制信号从巨噬细胞向淋巴细胞的传递是通过细胞接触实现的。
Br J Exp Pathol. 1983 Feb;64(1):87-92.
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Br J Exp Pathol. 1984 Apr;65(2):267-73.
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