Brown D, Hansen J, Ehrenfeld E
J Virol. 1980 May;34(2):573-5. doi: 10.1128/JVI.34.2.573-575.1980.
Crude initiation factor preparations from poliovirus-infected cells stimulated the translation of poliovirus RNA in vitro, but were inactive for the translation of host cell or vesicular stomatitis virus mRNA's. In contrast, similar preparations from either uninfected or vesicular stomatitis virus-infected cells supported the initiation of translation of host cell mRNA's and both viral mRNA's. These results reflect a specific alteration of some components(s) of the initiation factor preparation from poliovirus-infected cells which is consistent with the ability of the virus to inhibit the translation of host cell and vesicular stomatitis virus-directed protein synthesis.
从感染脊髓灰质炎病毒的细胞中提取的粗制起始因子制剂，能在体外刺激脊髓灰质炎病毒RNA的翻译，但对宿主细胞或水疱性口炎病毒mRNA的翻译无活性。相比之下，从未感染或感染水疱性口炎病毒的细胞中提取的类似制剂，能支持宿主细胞mRNA以及两种病毒mRNA的起始翻译。这些结果反映了来自感染脊髓灰质炎病毒的细胞的起始因子制剂中某些成分的特异性改变，这与该病毒抑制宿主细胞和水疱性口炎病毒指导的蛋白质合成的翻译能力是一致的。
