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1
Computerized microacidimetric determination of beta lactamase Michaelis-Menten constants.β-内酰胺酶米氏常数的计算机化微酸量滴定法测定
FEBS Lett. 1973 Jun 15;33(1):42-4. doi: 10.1016/0014-5793(73)80154-1.
2
Beta-lactamase activity in anaerobic bacteria.厌氧菌中的β-内酰胺酶活性
Antimicrob Agents Chemother. 1976 Jul;10(1):106-11. doi: 10.1128/AAC.10.1.106.
3
Enzymatic and immunological characterization of a new cephalosporinase from Enterobacter aerogenes.产气肠杆菌新型头孢菌素酶的酶学和免疫学特性
Antimicrob Agents Chemother. 1977 Aug;12(2):201-5. doi: 10.1128/AAC.12.2.201.
4
Cefoxitin resistance to beta-lactamase: a major factor for susceptibility of bacteroides fragilis to the antibiotic.头孢西丁对β-内酰胺酶的耐药性：脆弱拟杆菌对抗生素敏感性的一个主要因素。
Antimicrob Agents Chemother. 1977 Apr;11(4):725-34. doi: 10.1128/AAC.11.4.725.
5
Cefoxitin, a semi-synthetic cephamycin: a microbiological overview.
J Antimicrob Chemother. 1978 Jul;4(B):15-32. doi: 10.1093/jac/4.suppl_b.15.
6
Activity of HR 756 against Haemophilus influenzae, Bacteroides fragilis and Gram-negative rods.HR 756对流感嗜血杆菌、脆弱拟杆菌和革兰氏阴性杆菌的活性。
J Antimicrob Chemother. 1978 Sep;4(5):445-50. doi: 10.1093/jac/4.5.445.
7
Cefotoxime (HR 756) a new cephalosporin with exceptional broad-spectrum activity in vitro.头孢噻肟（HR 756）是一种新型头孢菌素，在体外具有卓越的广谱活性。
J Antimicrob Chemother. 1978 Sep;4(5):437-44. doi: 10.1093/jac/4.5.437.
8
beta-Lactamases of subspecies of Bacteroides fragilis.
J Antimicrob Chemother. 1978 Jul;4(B):47-54. doi: 10.1093/jac/4.suppl_b.47.
9
HR 756, a highly active cephalosporin: comparison with cefazolin and carbenicillin.HR 756，一种高效头孢菌素：与头孢唑林和羧苄青霉素的比较。
Antimicrob Agents Chemother. 1978 Dec;14(6):807-11. doi: 10.1128/AAC.14.6.807.
10
Susceptibility to beta-lactam antibiotics and production of beta-lactamase in Bacteroides fragilis.脆弱拟杆菌对β-内酰胺类抗生素的敏感性及β-内酰胺酶的产生
Med Microbiol Immunol. 1977 Oct 7;163(3):183-94. doi: 10.1007/BF02126677.

脆弱拟杆菌β-内酰胺酶对头孢噻肟的水解作用。

Hydrolysis of Cefotaxime by a beta-lactamase from Bacteroides fragilis.

作者信息

Pechère J C, Guay R, Dubois J, Letarte R

出版信息

Antimicrob Agents Chemother. 1980 Jun;17(6):1001-3. doi: 10.1128/AAC.17.6.1001.

DOI:10.1128/AAC.17.6.1001
PMID:6250465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283918/
Abstract

A beta-lactamase isolated from a strain of Bacteroides fragilis subsp. fragilis possessed hydrolytic activity toward cefotaxime. This antibiotic was degraded to a lower extent than was cephalothin, cephaloridine, and cefamandole, whereas cefoxitin remained unaffected by the enzyme. Kinetic parameters Vmax and Km for cefotaxime were calculated at 0.172 mumol/min and 1.1 X 10(-2) mM, respectively.

摘要

从脆弱拟杆菌脆弱亚种的一个菌株中分离出的一种β-内酰胺酶对头孢噻肟具有水解活性。与头孢噻吩、头孢啶和头孢孟多相比，这种抗生素的降解程度较低，而头孢西丁不受该酶的影响。头孢噻肟的动力学参数Vmax和Km分别计算为0.172 μmol/分钟和1.1×10⁻² mM。