一种无核酸疱疹亚单位疫苗的疗效
Efficacy of a nucleic acid free herpetic subunit vaccine.
作者信息
Cappel R, de Cuyper F, Rickaert F
出版信息
Arch Virol. 1980;65(1):15-23. doi: 10.1007/BF01340536.
PMID:6252864
Abstract
The efficacy of immunization with an herpes simplex subunit vaccine, free of nucleic acid, was evaluated in mice, rabbits and monkeys. One injection of 3 micrograms per kg of body weight elicited both humoral and cell-mediated immunity in all the animals studied. Furthermore, the immunization reduced significantly the mortality to a subsequent challenge with live herpes simplex virus in mice and rabbits (p less than 0.01).
摘要
对一种不含核酸的单纯疱疹亚单位疫苗在小鼠、兔子和猴子身上进行了免疫效果评估。每千克体重注射3微克一次，在所有研究的动物中均引发了体液免疫和细胞介导免疫。此外，免疫显著降低了小鼠和兔子随后感染活单纯疱疹病毒的死亡率（p小于0.01）。
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