真核生物和病毒信使RNA前体中剪接连接的二级结构。
Secondary structures for splice junctions in eukaryotic and viral messenger RNA precursors.
作者信息
Trapnell B C, Tolstoshev P, Crystal R G
出版信息
Nucleic Acids Res. 1980 Aug 25;8(16):3659-72. doi: 10.1093/nar/8.16.3659.
Abstract
Thermodynamically stable secondary structures have been found for adjacent splice junctions of 17 introns from 10 eukaryotic and viral mRNA precursors. Complementary regions in these structures position the exons to be ligated in a favourable orientation for splicing. The possible role of these structures in a general splicing mechanism in described.
摘要
已发现来自10种真核生物和病毒mRNA前体的17个内含子的相邻剪接连接处存在热力学稳定的二级结构。这些结构中的互补区域将待连接的外显子定位在有利于剪接的方向上。文中描述了这些结构在一般剪接机制中可能发挥的作用。
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