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噬菌体λ的int-xis-Pi区域的DNA序列；int和xis基因的重叠

DNA sequence of the int-xis-Pi region of the bacteriophage lambda; overlap of the int and xis genes.

作者信息

Davies R W

出版信息

Nucleic Acids Res. 1980 Apr 25;8(8):1765-82. doi: 10.1093/nar/8.8.1765.

DOI:10.1093/nar/8.8.1765
PMID:6253947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC324034/
Abstract

The DNA sequence of the int and xis genes of lambda bacteriophage, as well as that of the PI promoter and a region of unknown function beyond this, was determined by the chain termination procedure. The Pribnow box sequence of the PI promoter lies just within the xis gene, and both possible sites of mRNA initiation from PI are within the xis gene. The end of the xis gene in its turn overlaps the start of the int gene by 23 base pairs, in a different reading frame. This overlap may play a role in ensuring efficient excision of the prophage in response to natural induction signals.

摘要

通过链终止法测定了λ噬菌体int和xis基因的DNA序列，以及PI启动子的序列和此之外功能未知区域的序列。PI启动子的Pribnow框序列恰好位于xis基因内，并且从PI起始mRNA的两个可能位点都在xis基因内。xis基因的末端又与int基因的起始端在不同的阅读框中重叠23个碱基对。这种重叠可能在确保原噬菌体响应自然诱导信号而有效切除中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e1a/324034/d66916fad099/nar00425-0084-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e1a/324034/d66916fad099/nar00425-0084-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e1a/324034/d66916fad099/nar00425-0084-a.jpg

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本文引用的文献

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Integration-negative (int) mutants of phage lambda.噬菌体λ的整合阴性（int）突变体。
Virology. 1967 Jan;31(1):189. doi: 10.1016/0042-6822(67)90030-x.
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Retroregulation of the int gene of bacteriophage lambda: control of translation completion.噬菌体λ int基因的反向调控：翻译完成的控制
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4475-9. doi: 10.1073/pnas.78.7.4475.
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Posttranscriptional control of bacteriophage lambda gene expression from a site distal to the gene.噬菌体λ基因表达在远离该基因的位点的转录后调控。
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Mutational analysis of a regulatory region in bacteriophage lambda that has overlapping signals for the initiation of transcription and translation.对噬菌体λ中一个调控区域的突变分析，该区域具有转录和翻译起始的重叠信号。
Proc Natl Acad Sci U S A. 1984 Jan;81(2):555-9. doi: 10.1073/pnas.81.2.555.
9
The integrase family of site-specific recombinases: regional similarities and global diversity.位点特异性重组酶的整合酶家族：区域相似性与全球多样性
EMBO J. 1986 Feb;5(2):433-40. doi: 10.1002/j.1460-2075.1986.tb04229.x.
10
Cross-specificities between cII-like proteins and pRE-like promoters of lambdoid bacteriophages.类λ噬菌体的cII样蛋白与pRE样启动子之间的交叉特异性
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Evidence for a prophage excision gene in lambda.λ噬菌体中前噬菌体切除基因的证据。
J Mol Biol. 1970 Feb 14;47(3):557-64. doi: 10.1016/0022-2836(70)90322-0.
5
Supercoiled circular DNA-protein complex in Escherichia coli: purification and induced conversion to an opern circular DNA form.大肠杆菌中的超螺旋环状DNA-蛋白质复合物：纯化及诱导转化为开放环状DNA形式
Proc Natl Acad Sci U S A. 1969 Apr;62(4):1159-66. doi: 10.1073/pnas.62.4.1159.
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Mutants of bacteriophage lambda unable to integrate into the host chromosome.无法整合到宿主染色体中的噬菌体λ突变体。
Proc Natl Acad Sci U S A. 1967 Oct;58(4):1507-14. doi: 10.1073/pnas.58.4.1507.
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Prophage lambda at unusual chromosomal locations. II. Mutations induced by bacteriophage lambda in Escherichia coli K12.异常染色体位置上的λ原噬菌体。II. 大肠杆菌K12中噬菌体λ诱导的突变
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8
How ribosomes select initiator regions in mRNA: base pair formation between the 3' terminus of 16S rRNA and the mRNA during initiation of protein synthesis in Escherichia coli.核糖体如何在mRNA中选择起始区域：大肠杆菌蛋白质合成起始过程中16S rRNA的3'末端与mRNA之间的碱基对形成
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Phage lambda receptor chromosomes for DNA fragments made with restriction endonuclease III of Haemophilus influenzae and restriction endonuclease I of Escherichia coli.用于由流感嗜血杆菌的限制性内切核酸酶III和大肠杆菌的限制性内切核酸酶I制备的DNA片段的噬菌体λ受体染色体。
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Studies on the cleavage of bacteriophage lambda DNA with EcoRI Restriction endonuclease.用EcoRI限制性内切酶切割噬菌体λ DNA的研究。
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