克隆的哈维鼠肉瘤病毒DNA介导的转化：长末端重复DNA提高转化效率。
Transformation by cloned Harvey murine sarcoma virus DNA: efficiency increased by long terminal repeat DNA.
作者信息
Chang E H, Ellis R W, Scolnick E M, Lowy D R
出版信息
Science. 1980 Dec 12;210(4475):1249-51. doi: 10.1126/science.6254153.
PMID:6254153
Abstract
The coding sequences for the transforming (src) protein (p21) of Harvey murine sarcoma virus have been localized to a 1.3 kilobase pair segment near the 5' end of the viral genome. Ligation of the viral terminal repeat DNA to the left end of the src region DNA markedly enhanced the low transforming efficiency of the src region DNA.
摘要
哈维鼠肉瘤病毒的转化（src）蛋白（p21）的编码序列已定位到病毒基因组5'端附近的一个1.3千碱基对片段上。将病毒末端重复DNA连接到src区域DNA的左端，显著提高了src区域DNA的低转化效率。
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