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循环人B细胞中J链及分泌成分结合位点的研究。II. 细胞质

Studies on J chain and binding site for secretory component in circulating human B cells. II. The cytoplasm.

作者信息

Brandtzaeg P

出版信息

Clin Exp Immunol. 1976 Jul;25(1):59-66.

PMID:62631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541378/
Abstract

About 0-3-1-1% of the lymphoid cells from peripheral blood of healthy adults contained cytoplasmic immunoglobulin (Ig). The class distribution of these B cells varied greatly among individuals, with a preponderance of the IgA (26-65%) or the IgG (15-66%) class. A remarkably high percentage of the Ig-containing cells were positive for cytoplasmic J chain regardless of the class (100% for IgM, 87-97% for IgA, 50-100% FOR IgD, and 43-88% for IgG cells). This feature probably reflects that the cells represent circulating blasts derived from the early expansion phase of B-cell clones. The antigenic determinants of the J chain were in most IgA-containing cells considerably masked, indicating that this subunit was "correctly" arranged in the IgA dimers at the cytoplasmic level in the manner demonstrated for intestinal IgA plasma cells.

摘要

健康成年人外周血中约0 - 3 - 1 - 1%的淋巴细胞含有细胞质免疫球蛋白（Ig）。这些B细胞的类别分布在个体间差异很大，以IgA类（26 - 65%）或IgG类（15 - 66%）占优势。无论类别如何，含Ig细胞中有相当高比例的细胞细胞质J链呈阳性（IgM细胞为100%，IgA细胞为87 - 97%，IgD细胞为50 - 100%，IgG细胞为43 - 88%）。这一特征可能反映这些细胞代表源自B细胞克隆早期扩增阶段的循环母细胞。在大多数含IgA的细胞中，J链的抗原决定簇被显著掩盖，表明该亚基在细胞质水平上以肠道IgA浆细胞所显示的方式“正确”排列在IgA二聚体中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59ae/1541378/b335214fd1ff/clinexpimmunol00245-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59ae/1541378/b335214fd1ff/clinexpimmunol00245-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59ae/1541378/b335214fd1ff/clinexpimmunol00245-0071-a.jpg

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本文引用的文献

1
Immunoglobulins as cell receptors.作为细胞受体的免疫球蛋白。
Ann N Y Acad Sci. 1971 Dec 31;190:420-31. doi: 10.1111/j.1749-6632.1971.tb13552.x.
2
Peyer's patches: lack of specific antibody-containing cells after oral and parenteral immunization.派尔集合淋巴结：经口服和肠胃外免疫后缺乏含特异性抗体的细胞。
J Immunol. 1971 Apr;106(4):938-45.
3
The synthesis and assembly of immunoglobulins by malignant human plasmacytes. 3. Heterogeneity in IgA polymer assembly.恶性人浆细胞免疫球蛋白的合成与组装。3. IgA聚合物组装的异质性。
IgA系膜增生性肾小球肾炎中循环淋巴细胞合成聚合IgA的速率增加。
Clin Exp Immunol. 1982 Feb;47(2):309-16.
4
Detection of monomeric and polymeric IgA containing immune complexes in serum and kidney from patients with alcoholic liver disease.酒精性肝病患者血清和肾脏中含免疫复合物的单体和聚合IgA的检测。
Clin Exp Immunol. 1982 Feb;47(2):327-35.
5
Detection of polymeric IgA in glomeruli from patients with IgA nephropathy.IgA肾病患者肾小球中聚合IgA的检测。
Clin Exp Immunol. 1982 Aug;49(2):419-25.
6
Detection of J chain in lymphomas and related disorders.淋巴瘤及相关疾病中J链的检测。
Clin Exp Immunol. 1981 Jun;44(3):620-8.
7
Differentiation between benign and malignant monoclonal gammopathy by the presence of the J chain.通过J链的存在来鉴别良性和恶性单克隆丙种球蛋白病。
Clin Exp Immunol. 1981 May;44(2):375-82.
8
Presence of J chain in human lymphoid cells.人淋巴细胞中J链的存在。
Clin Exp Immunol. 1980 Feb;39(2):371-85.
9
Quantitative immunohistochemistry of immunoglobulin- and J-chain-producing cells in human parotid and submandibular salivary glands.人腮腺和颌下唾液腺中产生免疫球蛋白和J链细胞的定量免疫组织化学研究
Immunology. 1980 Feb;39(2):129-40.
10
Significance of different J chain profiles in human tissues: generation of IgA and IgM with binding site for secretory component is related to the J chain expressing capacity of the total local immunocyte population, including IgG and IgD producing cells, and depends on the clinical state of the tissue.人组织中不同J链谱的意义：具有分泌成分结合位点的IgA和IgM的产生与包括产生IgG和IgD的细胞在内的局部免疫细胞总体的J链表达能力有关，并取决于组织的临床状态。
Clin Exp Immunol. 1984 Dec;58(3):709-18.
Eur J Immunol. 1974 May;4(5):367-9. doi: 10.1002/eji.1830040512.
4
The non-specific stimulation of immunoglobulin secretion following specific stimulation of the immune system.免疫系统受到特异性刺激后免疫球蛋白分泌的非特异性刺激。
Immunology. 1974 Sep;27(3):401-12.
5
The life span of IgA plasma cells from the mouse intestine.来自小鼠肠道的IgA浆细胞的寿命。
J Exp Med. 1973 Aug 1;138(2):452-60. doi: 10.1084/jem.138.2.452.
6
Immunofluorescence studies on immunoglobulins in the lymphoid cells of human peripheral blood.人外周血淋巴细胞中免疫球蛋白的免疫荧光研究。
Clin Exp Immunol. 1972 Aug;11(4):483-94.
7
Cell surface immunoglobulin. VII. Synthesis, shedding, and secretion of immunoglobulin by lymphoid cells of germ-free mice.细胞表面免疫球蛋白。VII。无菌小鼠淋巴细胞免疫球蛋白的合成、脱落及分泌
J Exp Med. 1974 Apr 1;139(4):862-76. doi: 10.1084/jem.139.4.862.
8
Human nasal exocrine IgA antibody: formation and some activities.人鼻外分泌型 IgA 抗体：形成及一些活性
Adv Exp Med Biol. 1974;45(0):463-5. doi: 10.1007/978-1-4613-4550-3_55.
9
Presence of J chain in human immunocytes containing various immunoglobulin classes.在含有各种免疫球蛋白类别的人类免疫细胞中J链的存在。
Nature. 1974 Nov 29;252(5482):418-20. doi: 10.1038/252418a0.
10
IgM-forming cells as the immediate precursor of IgA-producing cells during ontogeny of the immunoglobulin-producing system of the chicken.在鸡免疫球蛋白产生系统个体发育过程中，形成IgM的细胞作为产生IgA细胞的直接前体。
J Immunol. 1974 Jul;113(1):120-6.