整合的猴病毒40 DNA：细胞-病毒重组连接点处的核苷酸序列。
Integrated simian virus 40 DNA: nucleotide sequences at cell-virus recombinant junctions.
作者信息
Stringer J R
出版信息
J Virol. 1981 May;38(2):671-9. doi: 10.1128/JVI.38.2.671-679.1981.
DNA fragments containing the integrated viral DNA present in the simian virus 40 (SV40)-transformed rat cell lines SVRE9 and SVRE17 were cloned in procaryotic vectors, and the DNA sequences linking SV40 and cell DNA were determined. Comparison of the DNA sequences at the SV40-cell junctions in SVRE9 and SVRE17 cells with those of a previously characterized viral insertion from SV14B cells shows that no specific viral or cellular sequences occur at SV40-cell junctions and that the cellular DNA sequences adjacent to integrated SV40 DNA do not display the direct repeat structure characteristic of transposons and retrovirus proviruses.
将存在于猿猴病毒40（SV40）转化的大鼠细胞系SVRE9和SVRE17中的含有整合病毒DNA的DNA片段克隆到原核载体中，并确定连接SV40和细胞DNA的DNA序列。将SVRE9和SVRE17细胞中SV40-细胞连接处的DNA序列与先前表征的来自SV14B细胞的病毒插入序列进行比较，结果表明在SV40-细胞连接处未出现特定的病毒或细胞序列，并且与整合的SV40 DNA相邻的细胞DNA序列不显示转座子和逆转录病毒前病毒的直接重复结构特征。
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