在一家康复医院急性传染性非细菌性胃肠炎暴发期间分离出的一种27纳米病毒：一种可能的新血清型。

A 27-nm virus isolated during an outbreak of acute infectious nonbacterial gastroenteritis in a convalescent hospital: a possible new serotype.

作者信息

Oshiro L S, Haley C E, Roberto R R, Riggs J L, Croughan M, Greenberg H, Kapikian A

出版信息

J Infect Dis. 1981 Jun;143(6):791-5. doi: 10.1093/infdis/143.6.791.

DOI:10.1093/infdis/143.6.791

Abstract

An outbreak of acute infectious nonbacterial gastroenteritis began among elderly patients in a convalescent hospital in Marin County in northern California in March 1978 and persisted through May 1978. The overall clinical attack rate was 51% of 187 residents and 12% of 180 employees. A 27-nm viruslike particle was observed by immune electron microscopy in stools obtained at or near the onset of illness from four of 32 patients. Seroresponses to the 27-nm particles were found by immune electron microscopy in 16 of 18 patients. In addition, serologic evidence of infection with this or a related agent was demonstrated in persons who developed illness in another large outbreak of acute infectious nonbacterial gastroenteritis which occurred in a nearby county. This agent is morphologically similar to but serologically unrelated to the Norwalk and Hawaii gastroenteritis agents and has been designated the Marin agent pending further classification.

摘要

1978年3月，加利福尼亚州北部马林县一家康复医院的老年患者中爆发了急性传染性非细菌性肠胃炎，并持续至1978年5月。187名住院患者的总体临床发病率为51%，180名员工的发病率为12%。通过免疫电子显微镜在32名患者中4名发病时或发病前后采集的粪便中观察到一种27纳米的病毒样颗粒。通过免疫电子显微镜在18名患者中的16名发现了对27纳米颗粒的血清反应。此外，在附近一个县发生的另一次急性传染性非细菌性肠胃炎大爆发中发病的人员中，也证明了感染这种或相关病原体的血清学证据。这种病原体在形态上与诺沃克和夏威夷肠胃炎病原体相似，但血清学上无关，在进一步分类之前被命名为马林病原体。