• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过免疫电子显微镜观察到与急性感染性非细菌性肠胃炎相关的一种27纳米颗粒。

Visualization by immune electron microscopy of a 27-nm particle associated with acute infectious nonbacterial gastroenteritis.

作者信息

Kapikian A Z, Wyatt R G, Dolin R, Thornhill T S, Kalica A R, Chanock R M

出版信息

J Virol. 1972 Nov;10(5):1075-81. doi: 10.1128/JVI.10.5.1075-1081.1972.

DOI:10.1128/JVI.10.5.1075-1081.1972
PMID:4117963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC356579/
Abstract

A 27-nm particle was observed by immune electron microscopy in an infectious stool filtrate derived from an outbreak in Norwalk, Ohio, of acute infectious nonbacterial gastroenteritis. Both experimentally and naturally infected individuals developed serological evidence of infection; this along with other evidence suggested that the particle was the etiological agent of Norwalk gastroenteritis.

摘要

在俄亥俄州诺沃克爆发的急性传染性非细菌性肠胃炎的一份传染性粪便滤液中，通过免疫电子显微镜观察到了一种27纳米的颗粒。无论是实验感染还是自然感染的个体都产生了感染的血清学证据；这与其他证据一起表明该颗粒是诺沃克肠胃炎的病原体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bfa/356579/7f3adf9161ef/jvirol00275-0202-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bfa/356579/adb6f1d1a4c5/jvirol00275-0198-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bfa/356579/b348029e7c32/jvirol00275-0198-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bfa/356579/618478e3dd14/jvirol00275-0199-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bfa/356579/53743cbd945f/jvirol00275-0200-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bfa/356579/6cc6f654e792/jvirol00275-0201-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bfa/356579/8e6af0af76d9/jvirol00275-0201-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bfa/356579/7f3adf9161ef/jvirol00275-0202-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bfa/356579/adb6f1d1a4c5/jvirol00275-0198-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bfa/356579/b348029e7c32/jvirol00275-0198-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bfa/356579/618478e3dd14/jvirol00275-0199-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bfa/356579/53743cbd945f/jvirol00275-0200-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bfa/356579/6cc6f654e792/jvirol00275-0201-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bfa/356579/8e6af0af76d9/jvirol00275-0201-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bfa/356579/7f3adf9161ef/jvirol00275-0202-a.jpg

相似文献

1
Visualization by immune electron microscopy of a 27-nm particle associated with acute infectious nonbacterial gastroenteritis.通过免疫电子显微镜观察到与急性感染性非细菌性肠胃炎相关的一种27纳米颗粒。
J Virol. 1972 Nov;10(5):1075-81. doi: 10.1128/JVI.10.5.1075-1081.1972.
2
Pattern of shedding of the Norwalk particle in stools during experimentally induced gastroenteritis in volunteers as determined by immune electron microscopy.通过免疫电子显微镜确定的志愿者实验性肠胃炎期间粪便中诺沃克病毒颗粒的排出模式。
J Infect Dis. 1975 Jul;132(1):28-34. doi: 10.1093/infdis/132.1.28.
3
Detection by immune electron microscopy of 26- to 27-nm viruslike particles associated with two family outbreaks of gastroenteritis.通过免疫电子显微镜检测与两起家庭肠胃炎暴发相关的26至27纳米病毒样颗粒。
J Infect Dis. 1977 Jan;135(1):20-7. doi: 10.1093/infdis/135.1.20.
4
Norwalk virus in Norway: an outbreak of gastroenteritis studied by electron microscopy and radioimmunoassay.挪威的诺如病毒：一次通过电子显微镜和放射免疫测定法研究的肠胃炎暴发。
Scand J Infect Dis. 1989;21(5):521-6. doi: 10.3109/00365548909037880.
5
Detection by immune electron microscopy of the Snow Mountain agent of acute viral gastroenteritis.用免疫电子显微镜检测急性病毒性肠胃炎的雪山因子。
J Infect Dis. 1982 Aug;146(2):184-9. doi: 10.1093/infdis/146.2.184.
6
Prevalence of antibody to the Norwalk agent by a newly developed immune adherence hemagglutination assay.通过新开发的免疫粘附血凝试验检测诺沃克病毒抗体的流行情况。
J Med Virol. 1978;2(4):281-94. doi: 10.1002/jmv.1890020402.
7
Solid-phase microtiter radioimmunoassay for detection of the Norwalk strain of acute nonbacterial, epidemic gastroenteritis virus and its antibodies.用于检测急性非细菌性流行性胃肠炎病毒诺沃克毒株及其抗体的固相微量滴定放射免疫测定法。
J Med Virol. 1978;2(2):97-108. doi: 10.1002/jmv.1890020204.
8
Oyster-associated gastroenteritis in Australia: the detection of Norwalk virus and its antibody by immune electron microscopy and radioimmunoassay.澳大利亚与牡蛎相关的肠胃炎：通过免疫电子显微镜和放射免疫分析法检测诺沃克病毒及其抗体。
J Med Virol. 1980;6(1):11-9. doi: 10.1002/jmv.1890060103.
9
A 27-nm virus isolated during an outbreak of acute infectious nonbacterial gastroenteritis in a convalescent hospital: a possible new serotype.在一家康复医院急性传染性非细菌性胃肠炎暴发期间分离出的一种27纳米病毒：一种可能的新血清型。
J Infect Dis. 1981 Jun;143(6):791-5. doi: 10.1093/infdis/143.6.791.
10
Reovirus-like agent in acute epidemic gastroenteritis in Japanese infants: fecal shedding and serologic response.日本婴儿急性流行性胃肠炎中的呼肠孤病毒样病原体：粪便排毒及血清学反应
J Infect Dis. 1977 Feb;135(2):259-66. doi: 10.1093/infdis/135.2.259.

引用本文的文献

1
The Impact of Norovirus on Children and Adolescents: Implications for Ongoing Vaccine Development.诺如病毒对儿童和青少年的影响：对正在进行的疫苗研发的启示
Curr Pediatr Rep. 2024;13(1):21. doi: 10.1007/s40124-025-00355-9. Epub 2025 Aug 13.
2
Genetic diversity of norovirus in Shenzhen Based on continuous surveillance from 2016 to 2022.基于2016年至2022年持续监测的深圳诺如病毒基因多样性
Front Cell Infect Microbiol. 2025 Jun 18;15:1593610. doi: 10.3389/fcimb.2025.1593610. eCollection 2025.
3
The saga to monitor and control norovirus: the rise of GII.17.

本文引用的文献

1
An indication as to identity between the infectious diarrhea in Japan and the afebrile infectious nonbacterial gastroenteritis by human volunteer experiments.通过人体志愿者实验对日本传染性腹泻与无热传染性非细菌性胃肠炎之间同一性的一种指示。
Jpn J Med Sci Biol. 1957 Feb;10(1):1-17. doi: 10.7883/yoken1952.10.1.
2
On an ECHO-like agent constantly recoverable from volunteers given Niigata strain of acute epidemic gastroenteritis.在一种类似回声的因子上，可不断从感染新潟株急性流行性肠胃炎的志愿者体内恢复得到。
Jpn J Exp Med. 1956 Aug;26(3-4):125-38.
3
A study of illness in a group of Cleveland families. XIII. Clinical description of acute nonbacterial gastroenteritis.
监测和控制诺如病毒的传奇故事：GII.17的崛起
J Gen Virol. 2025 Jun;106(6). doi: 10.1099/jgv.0.002118.
4
B cell lines fail to support efficient rhesus enteric calicivirus and human norovirus replication.B细胞系无法支持恒河猴肠道杯状病毒和人诺如病毒的有效复制。
J Virol. 2025 May 20;99(5):e0014325. doi: 10.1128/jvi.00143-25. Epub 2025 Apr 22.
5
Identification of Co-29, a 5-cyano-2-thiacetyl aromatic pyrimidinone, as a potential inhibitor targeting the RdRp of norovirus.鉴定5-氰基-2-硫代乙酰基芳香嘧啶酮Co-29作为靶向诺如病毒RNA依赖性RNA聚合酶（RdRp）的潜在抑制剂。
Virol J. 2025 Apr 4;22(1):93. doi: 10.1186/s12985-025-02687-w.
6
Vaccinia Virus Vector Bivalent Norovirus Vaccine.痘苗病毒载体二价诺如病毒疫苗
Viruses. 2025 Feb 9;17(2):237. doi: 10.3390/v17020237.
7
Genomic diversity and comparative phylogenomic analysis of genus Norovirus.诺如病毒属的基因组多样性及比较系统发育基因组学分析
Sci Rep. 2025 Feb 13;15(1):5412. doi: 10.1038/s41598-025-87719-9.
8
Activity and cryo-EM structure of the polymerase domain of the human norovirus ProPol precursor.人诺如病毒 ProPol 前体聚合酶结构域的活性和冷冻电镜结构。
J Virol. 2024 Nov 19;98(11):e0119324. doi: 10.1128/jvi.01193-24. Epub 2024 Oct 30.
9
Advances in human norovirus research: Vaccines, genotype distribution and antiviral strategies.人类诺如病毒研究进展：疫苗、基因型分布及抗病毒策略
Virus Res. 2024 Dec;350:199486. doi: 10.1016/j.virusres.2024.199486. Epub 2024 Oct 23.
10
Noroviruses: Evolutionary Dynamics, Epidemiology, Pathogenesis, and Vaccine Advances-A Comprehensive Review.诺如病毒：进化动力学、流行病学、发病机制及疫苗进展——全面综述
Vaccines (Basel). 2024 May 29;12(6):590. doi: 10.3390/vaccines12060590.
一组克利夫兰家庭的疾病研究。十三、急性非细菌性肠胃炎的临床描述
Am J Hyg. 1956 Nov;64(3):368-75. doi: 10.1093/oxfordjournals.aje.a119849.
4
The nonamebic nonbacillary diarrheal disorders.非阿米巴性非细菌性腹泻疾病
Am J Trop Med Hyg. 1955 Jul;4(4):739-55. doi: 10.4269/ajtmh.1955.4.739.
5
A study of illness in a group of Cleveland families. VII. Transmission of acute non-bacterial gastroenteritis to volunteers: evidence for two different etiologic agents.对一组克利夫兰家庭疾病的研究。VII. 急性非细菌性肠胃炎向志愿者的传播：两种不同病原体的证据。
J Exp Med. 1953 Nov;98(5):461-75. doi: 10.1084/jem.98.5.461.
6
A study of illness in a group of Cleveland families. I. Plan of study and certain general observations.对克利夫兰一组家庭疾病的研究。一、研究计划及某些一般性观察。
Am J Hyg. 1953 Jul;58(1):16-30. doi: 10.1093/oxfordjournals.aje.a119587.
7
Clinical laboratory studies in experimentally-induced epidemic nonbacterial gastroenteritis.实验性诱导的流行性非细菌性肠胃炎的临床实验室研究
J Lab Clin Med. 1953 Jan;41(1):133-41.
8
Winter vomiting disease.冬季呕吐病
J Infect Dis. 1969 Jun;119(6):668-73. doi: 10.1093/infdis/119.6.668.
9
Transmission of acute infectious nonbacterial gastroenteritis to volunteers by oral administration of stool filtrates.通过口服粪便滤液将急性传染性非细菌性胃肠炎传播给志愿者。
J Infect Dis. 1971 Mar;123(3):307-12. doi: 10.1093/infdis/123.3.307.
10
A virus from epidemic vomiting disease.一种来自流行性呕吐病的病毒。
Br Med J. 1972 Jul 8;3(5818):86-9. doi: 10.1136/bmj.3.5818.86.