人类星状病毒4型的流行率：衣壳蛋白序列及其与其他毒株的比较。
Prevalence of human astrovirus serotype 4: capsid protein sequence and comparison with other strains.
作者信息
Willcocks M M, Kurtz J B, Lee T W, Carter M J
机构信息
School of Biological Sciences, University of Surrey, Guildford, UK.
出版信息
Epidemiol Infect. 1995 Apr;114(2):385-91. doi: 10.1017/s0950268800058015.
Abstract
Astrovirus serotype 4 has increased in relative prevalence in the Oxford, UK area in 1993. The structural gene of human astrovirus serotype 4 has been sequenced and the results indicate that this protein differs substantially from serotypes 1 and 2. In particular, conservation at the C terminus is greatly reduced. However, amino acid substitutions in this region show a strong conservation in character suggesting that structural or functional constraints operate in this region.
摘要
1993年，星状病毒4型在英国牛津地区的相对流行率有所上升。人类星状病毒4型的结构基因已被测序，结果表明该蛋白与1型和2型有很大不同。特别是，C端的保守性大大降低。然而，该区域的氨基酸替换在性质上显示出很强的保守性，这表明该区域存在结构或功能限制。
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