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枯草芽孢杆菌中的限制与修饰：在温和噬菌体SPβ中鉴定出一个编码BsuR特异性修饰甲基转移酶的基因。

Restriction and modification in Bacillus subtilis: identification of a gene in the temperate phage SP beta coding for a BsuR specific modification methyltransferase.

作者信息

Trautner T A, Pawlek B, Günthert U, Canosi U, Jentsch S, Freund M

出版信息

Mol Gen Genet. 1980;180(2):361-7. doi: 10.1007/BF00425849.

DOI:10.1007/BF00425849
PMID:6258025
Abstract

A gene coding for a modifying DNA-methyltransferase which methylates the central C in the BsuR recognition sequence 5'GGCC was identified in the genome of the temperature Bacillus subtilis phage SP beta. This gene is expressed only after induction of the prophage by either mitomycin C or UV. The presence of active methyltransferase in induced cells leads to modification of BsuR recognition sites in SP beta DNA as well as in heterologous DNA.

摘要

在嗜温性枯草芽孢杆菌噬菌体SPβ的基因组中，鉴定出一个编码修饰性DNA甲基转移酶的基因，该酶可使BsuR识别序列5'GGCC中的中央C发生甲基化。这个基因仅在通过丝裂霉素C或紫外线诱导原噬菌体后才表达。诱导细胞中活性甲基转移酶的存在会导致SPβ DNA以及异源DNA中的BsuR识别位点发生修饰。

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Restriction and modification in Bacillus subtilis: identification of a gene in the temperate phage SP beta coding for a BsuR specific modification methyltransferase.枯草芽孢杆菌中的限制与修饰：在温和噬菌体SPβ中鉴定出一个编码BsuR特异性修饰甲基转移酶的基因。
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2
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