Miyamoto N, Nakamura H, Hayashi S
Jpn J Antibiot. 1981 Apr;34(4):495-99.
The following results have been obtained in our basic and clinical studies to examine a new cephalosporin derivative, cefotaxime (CTX). For basic study purpose, we injected 1 g of CTX to 6 patients who had received simple total hysterectomy and measured its level in elbow vein, uterine artery, corpus uteri, cervix uteri, endometrium, oviduct and ovary. Any definitive conclusion should not be drawn from these results, since they have too big variation. However, slightly higher levels were achieved cervix uteri and oviduct than in other organs in a same patient. For clinical evaluation, we tried this drug to 12 cases of female genital infections and 91.7% response rate was obtained. Our studied population includes 8 cases of adnexitis, 2 with pelvioperitonitis, 1 with panperitonitis, and 1 patient with BARTHOLIN abscess. Organisms were detected only in 3 cases, including S. aureus in one patient, Micrococcus sp. in one, and mixture of Klebsiella sp. and B. fragilis in 1. Puncture of DOUGLAS pouch was performed in 3 cases after the completion of therapy and all had negative results. No side effect was observed, and no significant difference was noted between pre- and post-therapy examinations of peripheral blood, hepatic function and renal function.
为研究一种新型头孢菌素衍生物头孢噻肟（CTX），我们开展了基础和临床研究，获得了以下结果。在基础研究中，我们给6例接受单纯全子宫切除术的患者静脉注射1克CTX，并测量其在肘静脉、子宫动脉、子宫体、子宫颈、子宫内膜、输卵管和卵巢中的浓度。由于这些结果差异太大，不应从中得出任何确定性结论。然而，在同一患者中，子宫颈和输卵管中的浓度略高于其他器官。在临床评估中，我们将此药用于12例女性生殖系统感染患者，有效率达91.7%。我们的研究对象包括8例附件炎、2例盆腔腹膜炎、1例全腹膜炎和1例巴氏腺脓肿患者。仅在3例患者中检测到病原体，其中1例为金黄色葡萄球菌，1例为微球菌属，1例为克雷伯菌属和脆弱拟杆菌混合感染。3例患者在治疗结束后进行了后穹窿穿刺，结果均为阴性。未观察到副作用，治疗前后外周血、肝功能和肾功能检查无显著差异。
