Simson I W
Gastroenterology. 1982 Feb;82(2):171-8.
This study was undertaken to establish the frequency of membranous obstruction of the inferior vena cava in South Africa, to characterize the pathology of the lesion and to define its relationship to hepatocellular carcinoma. Over a 9-yr period 101 cases of membranous obstruction of the inferior vena cava into the right atrium was occluded in all cases in which it was examined, and two basic patterns of the abnormality in the hepatic portion of the inferior vena cava have been described. The histologic picture in the liver was a chronic congestive fibrosis. In 44 cases of congestive fibrosis, diagnosed from liver biopsy specimens from black patients over a 5-yr period, vena caval membranes were demonstrated on cavography in 38 (86.4%). Hepatocellular carcinoma developed in 48 of the 101 cases (47.5%), indicating the importance of this defect in the pathogenesis of hepatocellular carcinoma in South Africa.
本研究旨在确定南非下腔静脉膜性梗阻的发生率，描述该病变的病理特征，并明确其与肝细胞癌的关系。在9年的时间里，对101例下腔静脉膜性梗阻病例进行了研究，所有病例的下腔静脉均阻塞并汇入右心房，同时描述了下腔静脉肝段异常的两种基本模式。肝脏的组织学表现为慢性充血性纤维化。在5年期间从黑人患者肝脏活检标本诊断出的44例充血性纤维化病例中，38例（86.4%）经腔静脉造影显示有腔静脉膜。101例病例中有48例（47.5%）发生肝细胞癌，表明该缺陷在南非肝细胞癌发病机制中具有重要意义。
