抗疱疹病毒胸苷类似物对水痘带状疱疹病毒的抑制作用。
Inhibitory effects of antiherpesviral thymidine analogs against varicella-zoster virus.
作者信息
Machida H, Kuninaka A, Yoshino H
出版信息
Antimicrob Agents Chemother. 1982 Feb;21(2):358-61. doi: 10.1128/AAC.21.2.358.
Abstract
Thymidine analogs highly active against herpes simplex virus were compared in their inhibitory action against seven strains of varicella-zoster virus by a plaque reduction assay. E-5-Bromovinyl-arabinosyluracil (BV-ara-U) was most active, followed by E-5 chlorovinyl-arabinosyluracil, E-5-bromovinyl-2'-deoxyuridine (BV-dUrd), 2'-fluoro-5-methyl-arabinosyluracil, 2'-fluoro-5-iodo-arabinosylcytosine, arabinosylthymine, 5-vinyl-arabinosyluracil, acycloguanosine, and 5-iodo-2'-deoxyuridine, in order to decreasing activity. BV-ara-U was more than 10 times as active as BV-dUrd and almost completely inhibited plaque development of five strains of varicella-zoster virus at a concentration as low as 1 ng/ml.
摘要
通过蚀斑减少试验，比较了对单纯疱疹病毒具有高活性的胸苷类似物对七株水痘 - 带状疱疹病毒的抑制作用。E-5-溴乙烯基阿拉伯糖基尿嘧啶（BV-ara-U）活性最高，其次是E-5-氯乙烯基阿拉伯糖基尿嘧啶、E-5-溴乙烯基-2'-脱氧尿苷（BV-dUrd）、2'-氟-5-甲基阿拉伯糖基尿嘧啶、2'-氟-5-碘阿拉伯糖基胞嘧啶、阿拉伯糖基胸腺嘧啶、5-乙烯基阿拉伯糖基尿嘧啶、阿昔洛韦和5-碘-2'-脱氧尿苷，活性依次降低。BV-ara-U的活性是BV-dUrd的10倍以上，在低至1 ng/ml的浓度下几乎完全抑制了五株水痘 - 带状疱疹病毒的蚀斑形成。
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