Hunter J M, Jones R S, Utting J E
J R Soc Med. 1982 May;75(5):336-40. doi: 10.1177/014107688207500509.
Atracurium is a new, non-depolarizing muscle relaxant which rapidly breaks down in vivo and appears to require neither renal nor hepatic function for its elimination. As the commonly used non-depolarizing muscle relaxants carry the risk of prolonged effect when used in anephric patients, atracurium appears to have special promise in this situation. A preliminary account of the successful use of the relaxant in 20 anephric patients is recorded and evidence presented that atracurium is, indeed, a suitable agent for use in patients with renal failure.
阿曲库铵是一种新型非去极化肌松药,在体内迅速分解,其消除似乎既不依赖肾功能也不依赖肝功能。由于常用的非去极化肌松药用于无肾患者时有延长作用的风险,阿曲库铵在这种情况下似乎有特殊的应用前景。本文记录了该药在20例无肾患者中成功应用的初步情况,并提供证据表明阿曲库铵确实是适用于肾衰竭患者的药物。