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无肾患者使用肌肉松弛剂阿曲库铵:初步报告

Use of the muscle relaxant atracurium in anephric patients: preliminary communication.

作者信息

Hunter J M, Jones R S, Utting J E

出版信息

J R Soc Med. 1982 May;75(5):336-40. doi: 10.1177/014107688207500509.

Abstract

Atracurium is a new, non-depolarizing muscle relaxant which rapidly breaks down in vivo and appears to require neither renal nor hepatic function for its elimination. As the commonly used non-depolarizing muscle relaxants carry the risk of prolonged effect when used in anephric patients, atracurium appears to have special promise in this situation. A preliminary account of the successful use of the relaxant in 20 anephric patients is recorded and evidence presented that atracurium is, indeed, a suitable agent for use in patients with renal failure.

摘要

阿曲库铵是一种新型非去极化肌松药,在体内迅速分解,其消除似乎既不依赖肾功能也不依赖肝功能。由于常用的非去极化肌松药用于无肾患者时有延长作用的风险,阿曲库铵在这种情况下似乎有特殊的应用前景。本文记录了该药在20例无肾患者中成功应用的初步情况,并提供证据表明阿曲库铵确实是适用于肾衰竭患者的药物。

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引用本文的文献

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本文引用的文献

1
PROLONGED PARESIS FOLLOWING GALLAMINE; A CASE REPORT.
Br J Anaesth. 1963 Dec;35:804-6. doi: 10.1093/bja/35.12.804.
2
Evaluation of atracurium in anaesthetized man.阿曲库铵在麻醉人体中的评估。
Br J Anaesth. 1981 Jan;53(1):45-54. doi: 10.1093/bja/53.1.45.
6
Prolonged curarization in a patient with renal failure. Case report.
Br J Anaesth. 1971 May;43(5):506-8. doi: 10.1093/bja/43.5.506.
7
The muscle relaxants and their antagonists.肌肉松弛剂及其拮抗剂。
Br J Anaesth. 1970 Mar;42(3):235-48. doi: 10.1093/bja/42.3.235.

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