Carmel R, Johnson C S
N Engl J Med. 1978 Mar 23;298(12):647-50. doi: 10.1056/NEJM197803232981203.
Pernicious anemia affects primarily elderly northern Europeans, but may affect others more often than previously thought. Therefore, we analyzed the data from 156 documented cases: there were 73 patients of "European" origin, 52 black patients and 31 Latin-American patients. The mean age (+/- 1 S.D.) at presentation among black women, 53 +/- 16 years, was lower than that of all the others (P less than 0.001 in most comparisons), and seven of the 33 black women were less than 40 years old. In addition, 23 of the 24 black women tested had circulating antibody to intrinsic factor. A similar though less striking antibody prevalence (85 per cent) and age pattern (60 +/- 13 years) in Latin-American women did not reach statistical significance. No other group exceeded the usual 55 to 70 per cent prevalence of antibody. These finding suggest a different form of or a different response to the disease in black women and perhaps in Latin-American women.
恶性贫血主要影响北欧老年人群，但对其他人群的影响可能比之前认为的更为常见。因此，我们分析了156例确诊病例的数据：其中73例患者来自“欧洲”，52例为黑人患者，31例为拉丁裔患者。黑人女性患者就诊时的平均年龄（±1标准差）为53±16岁，低于其他所有患者（大多数比较中P<0.001），33名黑人女性中有7名年龄小于40岁。此外，接受检测的24名黑人女性中有23名体内存在抗内因子抗体。拉丁裔女性中抗体流行率（85%）和年龄模式（60±13岁）与之相似，但未达到统计学显著差异。其他组的抗体流行率均未超过通常的55%至70%。这些发现表明黑人女性以及可能还有拉丁裔女性对该疾病的表现形式或反应有所不同。
