抗病毒药物对小鼠巨细胞病毒诱导的巨噬细胞功能障碍的影响。
Effects of antiviral agents on murine cytomegalovirus-induced macrophage dysfunction.
作者信息
Shanley J D, Pesanti E L
出版信息
Infect Immun. 1982 Jun;36(3):918-23. doi: 10.1128/iai.36.3.918-923.1982.
Abstract
Infection of murine peritoneal macrophages with murine cytomegalovirus (MCMV) led to disruption of phagocytosis. This alteration of cellular behavior appeared to be an early event in viral replication appearing 24 to 36 h before virus production and 84 to 108 h before cell death. The effects of a variety of antiviral agents on both MCMV replication and MCMV-induced depression of phagocytosis were evaluated in vitro. Although all compounds thought to act by preventing viral DNA replication inhibited MCMV replication in macrophages, none prevented expression of virus-induced alteration of phagocytosis. Cycloheximide at 1 microM blocked viral replication and viral antigen expression and prevented depression of phagocytic activity.
摘要
用鼠巨细胞病毒（MCMV）感染小鼠腹膜巨噬细胞会导致吞噬作用受到破坏。这种细胞行为的改变似乎是病毒复制过程中的一个早期事件，出现在病毒产生前24至36小时以及细胞死亡前84至108小时。在体外评估了多种抗病毒药物对MCMV复制和MCMV诱导的吞噬作用抑制的影响。尽管所有被认为通过阻止病毒DNA复制起作用的化合物都能抑制巨噬细胞中的MCMV复制，但没有一种能阻止病毒诱导的吞噬作用改变的表达。1微摩尔的环己酰亚胺可阻断病毒复制和病毒抗原表达，并防止吞噬活性的抑制。
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