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Erythroid progenitors circulating in the blood of adult individuals produce fetal hemoglobin in culture.

作者信息

Papayannopoulou T, Nakamoto B, Buckley J, Kurachi S, Nute P E, Stamatoyannopoulos G

出版信息

Science. 1978 Mar 24;199(4335):1349-50. doi: 10.1126/science.628844.

DOI:10.1126/science.628844
PMID:628844
Abstract

Erythroid colonies, raised from erythroid stem cells circulating in the peripheral blood of normal adult individuals, synthesize considerable amounts of fetal hemoglobin. In cultures from persons with sickling disorders, amounts of hemoglobin F that are known to inhibit sickling in vivo are produced. The results provide evidence that primitive erythroid progenitors are able to express the hemoglobin F production program and that cultures of mononuclear cells of the adult blood can be used to investigate the mechanisms involved in regulation of gamma-globin gene switching.

摘要

相似文献

1
Erythroid progenitors circulating in the blood of adult individuals produce fetal hemoglobin in culture.
Science. 1978 Mar 24;199(4335):1349-50. doi: 10.1126/science.628844.
2
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6
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7
Serum-free culture of enriched hematopoietic progenitors reflects physiologic levels of fetal hemoglobin biosynthesis.富集造血祖细胞的无血清培养反映了胎儿血红蛋白生物合成的生理水平。
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8
Fetal to adult hemoglobin switch in cultures of early erythroid precursors from human fetuses and neonates.人胎儿和新生儿早期红系前体细胞培养中胎儿血红蛋白向成人血红蛋白的转换
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Synthesis of the minor fetal hemoglobin Fic in colonies of erythropoietic precursors isolated from human umbilical cord blood.从小儿脐带血中分离出的红细胞生成前体细胞集落中合成次要胎儿血红蛋白Fic。
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J Clin Invest. 1986 Dec;78(6):1497-503. doi: 10.1172/JCI112741.

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Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities.
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5
Serum factors can modulate the developmental clock of gamma- to beta-globin gene switching in somatic cell hybrids.血清因子可调节体细胞杂种中γ珠蛋白基因向β珠蛋白基因转换的发育时钟。
Mol Cell Biol. 1993 Aug;13(8):4844-51. doi: 10.1128/mcb.13.8.4844-4851.1993.
6
Membrane differentiation in human erythroid cells: unique profiles of cell surface glycoproteins expressed in erythroblasts in vitro from three ontogenic stages.人类红细胞系细胞中的膜分化：来自三个个体发育阶段的体外成红细胞所表达的细胞表面糖蛋白的独特谱型。
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3474-8. doi: 10.1073/pnas.77.6.3474.
7
Control of the simian fetal hemoglobin switch at the progenitor cell level.在祖细胞水平对猿猴胎儿血红蛋白转换的调控。
J Clin Invest. 1981 Feb;67(2):458-66. doi: 10.1172/JCI110054.
8
Cellular mechanisms for increased fetal hemoglobin production in culture. Evidence for continuous commitment to fetal hemoglobin production during burst formation.培养中胎儿血红蛋白产生增加的细胞机制。爆发形成过程中持续致力于胎儿血红蛋白产生的证据。
J Clin Invest. 1980 Nov;66(5):1175-8. doi: 10.1172/JCI109949.
9
Proportion of fetal hemoglobin synthesis decreases during erythroid cell maturation.在红细胞成熟过程中，胎儿血红蛋白合成的比例会降低。
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10
Sickle beta 0 thalassemia in Eastern Saudi Arabia.沙特阿拉伯东部的镰状β0地中海贫血
Am J Hum Genet. 1980 Jan;32(1):26-41.