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唾液免疫球蛋白A抗体及其他唾液成分对变形链球菌黏附于羟基磷灰石的干扰。

Interference of Salivary immunoglobulin A antibodies and other salivary fractions with adherence of Streptococcus mutans to hydroxyapatite.

作者信息

Gahnberg L, Olsson J, Krasse B, Carlén A

出版信息

Infect Immun. 1982 Aug;37(2):401-6. doi: 10.1128/iai.37.2.401-406.1982.

Abstract

The adherence of Streptococcus mutans to hydroxyapatite was studied in the presence of salivary fractions with varying activity of naturally occurring immunoglobulin A (IgA) antibodies. Human parotid saliva from different donors was fractionated by chromatography and compared. Salivary IgA antibodies had no decisive effect on the adherence of the S. mutans strain used. High-molecular-weight salivary components from some subjects had an adherence-promoting effect, whereas fractions collected after the void volume of a Sepharose 2B column always inhibited adherence. The data indicate that the influence of unfractionated saliva on adherence is dependent on the net effect of adherence-promoting and adherence-inhibiting components. This principle has to be considered when the effect of human saliva on microbial adherence is studied.

摘要

在具有不同活性的天然存在的免疫球蛋白A(IgA)抗体的唾液组分存在下,研究了变形链球菌对羟基磷灰石的粘附性。对来自不同供体的人腮腺唾液进行色谱分离并比较。唾液IgA抗体对所用变形链球菌菌株的粘附没有决定性作用。来自一些受试者的高分子量唾液成分具有促进粘附的作用,而在琼脂糖2B柱的空体积之后收集的组分总是抑制粘附。数据表明,未分级唾液对粘附的影响取决于促进粘附和抑制粘附成分的净效应。在研究人唾液对微生物粘附的影响时,必须考虑这一原则。

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