单次1克剂量头孢噻肟治疗产青霉素酶淋病奈瑟菌引起的感染。
Single 1 g dose of cefotaxime in the treatment of infections due to penicillinase-producing strains of Neisseria gonorrhoeae.
作者信息
de Koning G A, Tio D, van den Hoek J A, van Klingeren B
出版信息
Br J Vener Dis. 1983 Apr;59(2):100-2. doi: 10.1136/sti.59.2.100.
Abstract
One hundred and two patients with an uncomplicated infection due to penicillinase-producing strains of Neisseria gonorrhoeae (PPNG) were treated with a single 1 g dose of cefotaxime. At follow-up within 15 days all genital and rectal infections were cured. Pharyngeal infections also seemed to respond to this treatment. A relatively high proportion (30.9%) of patients, however, developed post-gonococcal urethritis.
摘要
102例因产青霉素酶淋病奈瑟菌（PPNG）引起单纯感染的患者接受了单次1g剂量头孢噻肟的治疗。在15天内的随访中，所有生殖器和直肠感染均得到治愈。咽部感染似乎也对这种治疗有反应。然而，相当高比例（30.9%）的患者发生了淋菌性尿道炎后尿道炎。
相似文献
1
Single 1 g dose of cefotaxime in the treatment of infections due to penicillinase-producing strains of Neisseria gonorrhoeae.单次1克剂量头孢噻肟治疗产青霉素酶淋病奈瑟菌引起的感染。
Br J Vener Dis. 1983 Apr;59(2):100-2. doi: 10.1136/sti.59.2.100.
2
Ceftriaxone in the treatment of ordinary and penicillinase-producing strains of Neisseria gonorrhoeae.头孢曲松治疗普通淋病奈瑟菌菌株和产青霉素酶淋病奈瑟菌菌株。
Br J Vener Dis. 1982 Oct;58(5):314-6. doi: 10.1136/sti.58.5.314.
3
Ceftizoxime (FK-749) is effective therapy for urethritis caused by penicillinase-producing Neisseria gonorrhoeae.头孢唑肟（FK-749）是治疗由产青霉素酶淋病奈瑟菌引起的尿道炎的有效疗法。
Sex Transm Dis. 1984 Jan-Mar;11(1):30-1. doi: 10.1097/00007435-198401000-00007.
4
Randomised comparative study of ceftriaxone and spectinomycin in gonorrhoea.头孢曲松与大观霉素治疗淋病的随机对照研究。
Genitourin Med. 1985 Apr;61(2):106-8. doi: 10.1136/sti.61.2.106.
5
Single dose cefoxitin in treating uncomplicated gonorrhoea caused by penicillinase producing Neisseria gonorrhoeae (PPNG) and non-PPNG strains.单剂量头孢西丁治疗由产青霉素酶淋病奈瑟菌（PPNG）和非PPNG菌株引起的无并发症淋病。
Genitourin Med. 1986 Aug;62(4):224-7. doi: 10.1136/sti.62.4.224.
6
Comparative study of treatment of uncomplicated gonorrhea with thiamphenicol and cefotaxime.
Sex Transm Dis. 1984 Oct-Dec;11(4 Suppl):379-81. doi: 10.1097/00007435-198410001-00016.
7
HR 756--a new cephalosporin in the treatment of gonorrhoea caused by ordinary and penicillinase-producing strains of Neisseria gonorrhoeae.HR 756——一种用于治疗由普通淋病奈瑟菌菌株和产青霉素酶淋病奈瑟菌菌株引起的淋病的新型头孢菌素。
Br J Vener Dis. 1980 Aug;56(4):255-8. doi: 10.1136/sti.56.4.255.
8
Single-dose treatment of uncomplicated gonorrhea in men with intramuscular and oral thiamphenicol.
Sex Transm Dis. 1984 Oct-Dec;11(4 Suppl):404-6. doi: 10.1097/00007435-198410001-00023.
9
Cefotaxime in the treatment of gonorrhoea caused by penicillinase producing N. gonorrhoeae (PPNG) and non penicillinase producing N. gonorrhoeae (Non PPNG).
J Med Assoc Thai. 1982 May;65(5):271-6.
引用本文的文献
1
Tolerability, Safety, Pharmacokinetics and Drug Interaction of Cefotaxime Sodium-Tazobactam Sodium Injection (6:1) Following Single and Multiple Intravenous Doses in Chinese Healthy Subjects.头孢噻肟钠-他唑巴坦钠注射液（6:1）在中国健康受试者中单次及多次静脉给药后的耐受性、安全性、药代动力学及药物相互作用
Front Pharmacol. 2020 Jul 8;11:1033. doi: 10.3389/fphar.2020.01033. eCollection 2020.
2
Beta-lactams in sexually transmitted diseases: rationale for selection and dosing regimens.β-内酰胺类药物在性传播疾病中的应用：选择依据及给药方案
Eur J Clin Microbiol. 1984 Dec;3(6):605-11. doi: 10.1007/BF02013632.
3
Role of cephalosporins in gonorrhoea and other sexually transmitted diseases.头孢菌素在淋病及其他性传播疾病中的作用。
Drugs. 1987;34 Suppl 2:164-79. doi: 10.2165/00003495-198700342-00013.
4
Cefotaxime. An update of its pharmacology and therapeutic use.头孢噻肟。其药理学与治疗应用的最新进展。
Drugs. 1990 Oct;40(4):608-51. doi: 10.2165/00003495-199040040-00008.
本文引用的文献
1
[The spread of penicillinase-forming gonococci in Amsterdam].[产青霉素酶淋球菌在阿姆斯特丹的传播]
Ned Tijdschr Geneeskd. 1982 Jan 30;126(5):221-3.
2
Gonorrhea in Rotterdam caused by penicillinase-producing gonococci.鹿特丹由产青霉素酶淋球菌引起的淋病。
Br J Vener Dis. 1980 Aug;56(4):244-8. doi: 10.1136/sti.56.4.244.
3
Treatment of uncomplicated gonorrhea with cefotaxime.用头孢噻肟治疗单纯性淋病。
Sex Transm Dis. 1981 Jul-Sep;8(3):187-91. doi: 10.1097/00007435-198107000-00003.
4
In vitro activity of cefotaxime and other cephalosporins against Neisseria gonorrhoeae.头孢噻肟及其他头孢菌素对淋病奈瑟菌的体外活性
J Antimicrob Chemother. 1980 Sep;6 Suppl A:47-50. doi: 10.1093/jac/6.suppl_a.47.
5
In vitro antimicrobial activity of cefoperazone, cefotaxime, moxalactam (LY127935), azlocillin, mezlocillin, and other beta-lactam antibiotics against Neisseria gonorrhoeae and Haemophilus influenzae, including beta-lactamase-producing strains.头孢哌酮、头孢噻肟、拉氧头孢（LY127935）、阿洛西林、美洛西林及其他β-内酰胺类抗生素对淋病奈瑟菌和流感嗜血杆菌的体外抗菌活性，包括产β-内酰胺酶菌株。
Antimicrob Agents Chemother. 1980 Apr;17(4):757-61. doi: 10.1128/AAC.17.4.757.
6
Cefotaxime for spectinomycin resistant Neisseria gonorrhoeae.头孢噻肟用于对壮观霉素耐药的淋病奈瑟菌。
Lancet. 1981 Jul 11;2(8237):96. doi: 10.1016/s0140-6736(81)90450-5.
7
Biochemical and genetical approaches to the mechanism of action of penicillin.青霉素作用机制的生化与遗传学研究方法。
Philos Trans R Soc Lond B Biol Sci. 1980 May 16;289(1036):273-83. doi: 10.1098/rstb.1980.0045.
8
Pharmacokinetics of cefotaxime.头孢噻肟的药代动力学。
Antimicrob Agents Chemother. 1979 Nov;16(5):592-7. doi: 10.1128/AAC.16.5.592.
Zotero 插件