在铁盐存在下超氧化物依赖性羟基自由基的形成及脂质过氧化。细胞外液中“催化性”铁的检测及抗氧化活性。
Superoxide-dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Detection of 'catalytic' iron and anti-oxidant activity in extracellular fluids.
作者信息
Gutteridge J M, Rowley D A, Halliwell B
出版信息
Biochem J. 1982 Sep 15;206(3):605-9. doi: 10.1042/bj2060605.
Abstract
Synovial fluid from rheumatoid patients and normal cerebrospinal fluid contains micromolar concentrations of non-protein-bound iron salts that can promote lipid peroxidation and also the superoxide-dependent formation of hydroxyl radicals from hydrogen peroxide. These iron catalysts of oxygen radical reactions cannot be detected by conventional assays unless interfering high-molecular-weight substances, probably proteins, are removed by ultrafiltration or inactivated by exposure to low pH values. The bleomycin assay for ;catalytic' iron [Gutteridge, Rowley & Halliwell (1981) Biochem. J.199, 263-265] does not suffer from these artifacts.
摘要
类风湿患者的滑液和正常脑脊液中含有微摩尔浓度的非蛋白结合铁盐，这些铁盐可促进脂质过氧化，还能通过超氧化物依赖的方式将过氧化氢转化为羟基自由基。除非通过超滤去除干扰性的高分子量物质（可能是蛋白质）或通过暴露于低pH值使其失活，否则这些氧自由基反应的铁催化剂无法通过常规检测方法检测到。用于检测“催化性”铁的博来霉素检测法[古特里奇、罗利和哈利威尔（1981年）《生物化学杂志》199卷，263 - 265页]不会受到这些假象的影响。
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