Omi Tokuya, Kawana Seiji
Department of Dermatology, Queens's Square Medical Center, Yokohama ; Department of Dermatology, Nippon Medical School, Tokyo , Japan.
Laser Ther. 2013;22(1):51-4. doi: 10.5978/islsm.13-or-07.
Molluscum contagiosum is caused by the molluscum contagiosum virus (MCV) and is a very common skin disorder mainly involving young children Cryotherapy, curettage or some topical therapies have been applied for MC, but all of these treatments need several sessions, can be somewhat ineffective, and very painful. The present study assessed the impact of a single session of pulsed dye laser treatment of MC lesions which had proved resistant to other approaches Subjects and methods: Fifteen children comprised the study subjects, 11 boys and 4 girls, 3-5 years of age (mean 4.2 yr) with recalcitrant MC. Lesions were counted at baseline, and a single shot from a 585 nm pulsed dye laser was applied to each lesion (3 mm, 300 ms, 8.0 J/cm(2)). Lesions were counted again at 1 week post-treatment and followed for up to 3 months thereafter.
All patients completed the study and no patient dropped out through pain or discomfort. Purpura was seen at each treated lesion immediately after irradiation, but at 1 week after treatment, lesion clearance was virtually complete which was maintained for 1 month, and no recurrence was seen at 3 months in 8 of the 15 patients who remained available for followup.
A single treatment of MC lesions with the pulsed dye laser successfully cured even recalcitrant lesions with no recurrence on follow up, and was well tolerated by the young subjects.
传染性软疣由传染性软疣病毒（MCV）引起，是一种常见的皮肤疾病，主要累及幼儿。冷冻疗法、刮除术或一些局部治疗方法已应用于传染性软疣，但所有这些治疗都需要多个疗程，可能效果不佳且非常疼痛。本研究评估了单次脉冲染料激光治疗对其他方法治疗无效的传染性软疣皮损的影响。
15名儿童作为研究对象，其中11名男孩和4名女孩，年龄3 - 5岁（平均4.2岁），患有难治性传染性软疣。在基线时对皮损进行计数，然后对每个皮损用585nm脉冲染料激光照射一次（3mm，300ms，8.0J/cm²）。在治疗后1周再次对皮损进行计数，并在此后随访长达3个月。
所有患者均完成研究，无患者因疼痛或不适退出。照射后每个治疗的皮损立即出现紫癜，但在治疗后1周，皮损清除几乎完全，且持续1个月，在15名可进行随访的患者中，8名患者在3个月时未见复发。
单次脉冲染料激光治疗传染性软疣皮损即使是难治性皮损也能成功治愈，随访无复发，且年轻患者耐受性良好。
