Postlethwaite A E, Lachman L B, Mainardi C L, Kang A H
J Exp Med. 1983 Feb 1;157(2):801-6. doi: 10.1084/jem.157.2.801.
Interleukin 1 is a monokine that exerts biological effects on a variety of target cells in vitro. In this report, interleukin 1 has been found to be capable of stimulating collagenase production by cultured dermal fibroblasts. The concentrations of interleukin 1 that stimulate fibroblast collagenase production are similar to those that stimulate mouse thymocyte proliferation. Analyses by high performance liquid chromatography indicate that interleukin 1, rather than a contaminating monokine, is responsible for this effect on fibroblasts. Interleukin 1, released in vivo by macrophages infiltrating sites of tissue damage or inflammation, may function to stimulate the release of collagenase by connective tissue fibroblasts.
白细胞介素1是一种单核因子，在体外对多种靶细胞发挥生物学效应。在本报告中，已发现白细胞介素1能够刺激培养的真皮成纤维细胞产生胶原酶。刺激成纤维细胞胶原酶产生的白细胞介素1浓度与刺激小鼠胸腺细胞增殖的浓度相似。高效液相色谱分析表明，对成纤维细胞产生这种作用的是白细胞介素1，而非污染性单核因子。浸润组织损伤或炎症部位的巨噬细胞在体内释放的白细胞介素1，可能起到刺激结缔组织成纤维细胞释放胶原酶的作用。
