小鼠微小病毒（一种自主细小病毒）的完整DNA序列。
The complete DNA sequence of minute virus of mice, an autonomous parvovirus.
作者信息
Astell C R, Thomson M, Merchlinsky M, Ward D C
出版信息
Nucleic Acids Res. 1983 Feb 25;11(4):999-1018. doi: 10.1093/nar/11.4.999.
Abstract
We have determined the complete nucleotide sequence of the genome of Minute Virus of Mice, an autonomous parvovirus. This single-stranded DNA is 5081 nucleotides long. The 3'-and 5'-ends of the viral strand contain imperfect palindromic sequences which consist, respectively, of 115 and 206 nucleotides. The 3'-terminal palindrome is composed of a unique sequence, whereas the 5'-terminal palindrome contains two sequences in equimolar amounts; these are related in that one is the inverted complement of the other. The DNA strand complementary to that which is encapsidated into virions contains two large open reading frames which together span almost the entire genome. Transcriptional and translational signals within the sequence have been identified and related to the known map coordinates of the viral transcripts. In this report we summarize some of the salient structural and organizational features of the MVM genome.
摘要
我们已经确定了自主细小病毒小鼠微小病毒（MVM）基因组的完整核苷酸序列。这条单链DNA长5081个核苷酸。病毒链的3'端和5'端含有不完全回文序列，分别由115和206个核苷酸组成。3'端回文由一个独特序列组成，而5'端回文含有等摩尔量的两个序列；它们的关系在于一个是另一个的反向互补序列。与包装进病毒粒子的链互补的DNA链含有两个大的开放阅读框，它们一起几乎跨越了整个基因组。已在该序列中鉴定出转录和翻译信号，并将其与病毒转录本的已知图谱坐标相关联。在本报告中，我们总结了MVM基因组的一些显著结构和组织特征。
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